Conventional chemotherapeutic regimens often accompany severe side effects and fail to induce complete regression of chemoresistant or relapsing metastatic cancers. The need for establishing more efficacious anticancer strategies led to the development of a combined modality treatment of chemotherapy in conjunction with immunotherapy or radiotherapy. It has been reported that poly-gamma-glutama...

We introduce a genetic algorithm GA with a new representation method which we call the proportional GA PGA The PGA is a multi character GA that relies on the exis tence or non existence of genes to determine the information that is expressed The in formation represented by a PGA individual depends only on what is present on the in dividual and not on the order in which it is present As a result...

A Parallel Genetic Algorithm (PGA) is used for a simulation-based optimization of waterway project schedules. This PGA is designed to distribute a Genetic Algorithm application over multiple processors in order to speed up the solution search procedure for a very large combinational problem. The proposed PGA is based on a global parallel model, which is also called a master-slave model. A Messa...

Many optimization problems have complex search space, which either increase the solving problem time or finish searching without obtaining the best solution. Genetic Algorithm (GA) is an optimization technique used in solving many practical problems in science, engineering, and business domains. Parallel Genetic Algorithm (PGA) has been widely used to increase speed of GA, especially after the ...

LY2157299 (LY), which is very small molecule bringing high cancer diffusion, is a pathway antagonist against TGFβ. LY dosage can be diluted by blood plasma, can be captured by immune system or it might be dissolved during digestion in gastrointestinal tract. The aim of our study is to optimize a "nano-elastic" carrier to avoid acidic pH of gastrointestinal tract, colon alkaline pH, and anti-imm...

BACKGROUND Scaffold-assisted autologous chondrocyte implantation is an effective clinical procedure for cartilage repair. From the regulatory point of view, the ovine model is one of the suggested large animal models for pre-clinical studies. The aim of our study was to evaluate the in vitro re-differentiation capacity of expanded ovine chondrocytes in biomechanically characterized polyglycolic...

OBJECTIVE Disease Extent Index-Takayasu (DEI.Tak) is a new index developed for the follow-up of Takayasu's arteritis (TA), assessing only clinical findings without the requirement of imaging. We investigated the effectiveness of DEI.Tak in assessing disease activity and progression by comparing with physician's global assessment (PGA) and active disease criteria defined by Kerr et al. METHODS...

We studied the folate requirements of a human acute lymphoblastic leukemia cell line, MOLT-3, and methotrexate (MTX)-resistant sublines established in vitro. The requirement of pteroylglutamate (PGA) for optimal cell growth was different for each cell line. With increasing MTX resistance, there was progressive increase in PGA requirements, moving the PGA concentration-cell growth curve (doseres...

Out of fifty-five Bacillus isolates obtained from ten different regional locations and sources, seven showed the ability to consistently produce specific extracellular polymeric substance (EPS) on rich as well as synthetic but nonspecific media which did not contain glutamic acid. The isolates were identified as either Bacillus licheniformis or Bacillus subtilis. The EPS from all isolates was r...

BACKGROUND During the last years B. megaterium was continuously developed as production host for the secretion of proteins into the growth medium. Here, recombinant production and export of B. megaterium ATCC14945 penicillin G amidase (PGA) which is used in the reverse synthesis of beta-lactam antibiotics were systematically improved. RESULTS For this purpose, the PGA leader peptide was repla...