Epilepsy surgery is highly effective in treating refractory epilepsy, but requires accurate presurgical localization of the epileptogenic focus. Briefly, localization of the region of seizure onset traditionally dependents on seizure semiology, scalp EEG recordings and correlation with anatomical imaging modalities such as MRI. The introduction of noninvasive functional neuroimaging methods, in...

In this study, use of a helical orbit in performing a long object SPECT scan with parallel, cone, fan, rotated fan, varying focal-length cone, divergent, and astigmatic collimators is proposed. Sufficient-data scanning helical orbits for these collimation geometries are developed. Both singledetector system and multi-detector system are considered. In order to verify our orbit design requiremen...

Background and Purpose—Patients with carotid occlusive disease and stage 2 cerebral hemodynamic failure, characterized by an increased oxygen extraction fraction (OEF) as measured by positron emission tomography (PET) and otherwise known as misery perfusion, have a high risk of cerebral ischemia and subsequent stroke. In clinical practice, the detection of patients with misery perfusion through...

relapse at low PSA values <1 ng ml−1, the obtained detection rates of 99mTc-labeled PSMA-SPECT/CT are lower than those reported by 68Ga-PSMA PET/CT imaging.1 This is in line with our experiences in early recurrent prostate cancer patients and low PSA values investigated with PSMA tracers for SPECT/CT imaging.3 Although very useful for PSMA-radioguided surgery,4,5 111 In-labeled PSMA I&T (or 99m...

BACKGROUND AND PURPOSE Patients with carotid occlusive disease and stage 2 cerebral hemodynamic failure, characterized by an increased oxygen extraction fraction (OEF) as measured by positron emission tomography (PET) and otherwise known as misery perfusion, have a high risk of cerebral ischemia and subsequent stroke. In clinical practice, the detection of patients with misery perfusion through...

In this paper, we extend a nonnegatively constrained iterative method and three stopping rules for its iterations to the medical imaging inverse problems of computed tomography (CT), positron emission tomography (PET), and single photon emission computed tomography (SPECT); the iterative method and stopping rules were introduced for use in astronomical imaging. The paper begins with a brief int...

This article reviews routine quality-control (QC) procedures for current nuclear medicine instrumentation, including the survey meter, dose calibrator, well counter, intraoperative probe, organ ("thyroid") uptake probe, gamma-camera, SPECT and SPECT/CT scanner, and PET and PET/CT scanner. It should be particularly useful for residents, fellows, and other trainees in nuclear medicine, nuclear ca...

As the world's population ages, the number of patients with Alzheimer's disease (AD) is predicted to increase rapidly. The presence of neurofibrillary tangles (NFTs), composed of hyperphosphorylated tau protein, is one of the neuropathological hallmarks of AD brain. Since the presence of NFTs is well correlated with neurodegeneration and cognitive decline in AD, imaging of tau using positron em...

BACKGROUND The detection of occult bone metastases is a key factor in determining the management of patients with renal cell carcinoma (RCC), especially when curative surgery is considered. This prospective study assessed the sensitivity of (18)F-labelled sodium fluoride in conjunction with positron emission tomography/computed tomography ((18)F-NaF PET/CT) for detecting RCC bone metastases, co...

BACKGROUND The purpose of the study is to evaluate whether a pinhole collimator is better adapted to bremsstrahlung single photon emission computed tomography [SPECT] than parallel-hole collimators and in the affirmative, to evaluate whether pinhole bremsstrahlung SPECT, including a simple model of the scatter inside the patient, could provide a fast dosimetry assessment in liver selective inte...