PURPOSE To assess the clinical value of computed tomography (CT) and magnetic resonance imaging (MRI) image fusion with 11C-acetate (AC) positron emission tomography (PET) imaging for detection and exact location of clinically occult recurrences. PATIENTS AND METHODS Fifty prostate cancer patients with elevated/increasing serum prostate-specific antigen levels after radical therapy underwent ...

Molecular brain imaging using positron emission tomography (PET) has evolved into a vigorous academic field and is progressively gaining importance in the clinical arena. Significant progress has been made in the design of high-resolution three-dimensional (3-D) PET units dedicated to brain research and the development of quantitative imaging protocols incorporating accurate image correction te...

The standard protocols described in this document cover subject preparation, injection activity, accumulation time, subject positioning, scan time and the criteria for determination of reconstruction parameters for each PET camera based on phantom data. The idea is to standardize the methods and conditions that would affect the PET image qualitatively or quantitatively. However, the image quali...

 Objective(s): 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET-CT) is a well-used and established technique for lung cancer staging. Radiation therapy requires accurate target volume delineation, which is difficult in most cases due to coexisting atelectasis. The present study was performed to compare the 18F-FDG PET-CT with contrast enhanced computed tomogr...

We evaluate an automated approach to the cortical surface mapping (CSM) method of VOI analysis in PET. Although CSM has been previously shown to be successful, the process can be long and tedious. Here, we present an approach that removes these difficulties through the use of 3D image warping to a common space. We test this automated method using studies of FDDNP PET in Alzheimer's disease and ...

Fusion of anatomic information in computed tomography (CT) and functional information in 18F-FDG positron emission tomography (PET) is crucial for accurate differentiation of tumor from benign masses, designing radiotherapy treatment plan and staging of cancer. Although current PET and CT images can be acquired from combined 18F-FDG PET/CT scanner, the two acquisitions are scanned separately an...

Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, NY, NY, USA Simultaneous MR/PET scanners allow for the exploration and development of novel PVE correction techniques without the challenges of coregistration of MR and PET. The development of a wavelet-based PVE correction method, to improve PET quantification, has proven successful in brain PET. We report ...

BACKGROUND In integrated PET/MR hybrid imaging the evaluation of PET performance characteristics according to the NEMA standard NU 2-2007 is challenging because of incomplete MR-based attenuation correction (AC) for phantom imaging. In this study, a strategy for CT-based AC of the NEMA image quality (IQ) phantom is assessed. The method is systematically evaluated in NEMA IQ phantom measurements...

In head and neck oncology, the information provided by positron emission tomography (PET)/CT and MRI is often complementary because both the methods are based on different biophysical foundations. Therefore, combining diagnostic information from both modalities can provide additional diagnostic gain. Debates about integrated PET/MRI systems have become fashionable during the past few years, sin...

Purpose. (124)I has a half-life of 4.2 days, which makes it suitable for imaging over several days over its uptake and washout phases. However, it has a low positron branching ratio (23%), because of prompt gamma coincidence due to high-energy γ-photons (602 to 1,691 keV), which are emitted in cascade with positrons. Methods. In this study, we investigated the optimal PET energy window for (124...