نتایج جستجو برای: peroxiredoxin
تعداد نتایج: 1912 فیلتر نتایج به سال:
Thiol peroxidase (Tpx) is an atypical 2-Cys peroxiredoxin, which has been suggested to be important for cell survival and virulence in Gram-negative pathogens. The structure of a catalytically inactive version of this protein in an orthorhombic crystal form has been determined by molecular replacement. Structural alignments revealed that Tpx is conserved. Analysis of the crystal packing shows t...
BACKGROUND Typical 2-Cys peroxiredoxin (Prx) is inactivated by overoxidation of the peroxidatic cysteine residue under oxidative stress. However, the significance in the context of vascular disease is unknown. METHODS AND RESULTS Immunohistochemical analyses revealed that 2-Cys Prxs, particularly Prx type II, are heavily overoxidized in balloon-injured rodent carotid vessels and in human athe...
In a recent issue of Blood, Agrawal-Singh et al reported the identification of PRDX2 (peroxiredoxin 2) as a novel tumor suppressor gene in acute myeloid leukemia (AML). The authors observed recurrent histone H3 deacetylation and DNA hypermethylation at the PRDX2 promoter region in primary leukemia samples. Epigenetic alterations correlated with low expression of PRDX2 protein and were associate...
Background: Peroxiredoxin 4 (PRDX4), a secreted antioxidant enzyme, can protect against hepatocellular carcinoma and lung adenocarcinoma, but its role in papillary thyroid (PTC) is still unclear. In this study, we investigated the association of PRDX4 expression with prognosis patients advanced PTC. Methods: We conducted retrospective case-control study at Kanazawa Medical University Hospital. ...
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