Insulin resistance (IR) is now considered as a chronic and low level inflammatory condition. It is closely related to altered glucose tolerance, hypertriglyceridemia, abdominal obesity, and coronary heart disease. IR is accompanied by the increase in the levels of inflammatory cytokines like interleukin-1 and 6, tumor necrosis factor-α. These inflammatory cytokines also play a crucial part in p...

Periodontitis is one of the most common oral infections induced by bacteria and bacterial products of dental plaque and is characterized by inflammatory destruction of tooth supporting connective tissues and alveolar bone. Recently, an association between periodontitis and cardiovascular disease has received considerable attention. The present study was carried out to assess the possible mechan...

There is an epidemiological association between periodontitis and cardiovascular disease (CVD). In periodontitis, low grade systemic inflammation and bacteremia occur regularly. Such events may contribute to platelet activation and subsequent pro-coagulant state. This study aimed to investigate platelet activation in periodontitis patients. The study is composed of two parts. In the first part,...

OBJECTIVE To study the extent of periodontal disease in diabetic and non-diabetic periodontitis patients, and to investigate the relationship of dyslipidemia and periodontal disease, in diabetic and non-diabetic periodontitis patients. METHODS This is a cross-sectional study at the Department of Preventive Dental Sciences (College of Dentistry) and Department of Physiology (College of Medicin...

Periodontitis has been linked to clinical cardiovascular disease but not to subclinical atherosclerosis. The purpose of this study was to determine whether periodontitis is associated with carotid artery intima-media wall thickness (IMT). Cross-sectional data on 6017 persons aged 52 to 75 years were obtained from the Atherosclerosis Risk in Communities Study 1996 to 1998 examination. The depend...

To determine the prevalence of aggressive periodontitis and associated systemic manifestations in Moradabad district, Uttar Pradesh, India. 3000 patients, including 1872 males and 1128 females were evaluated with mean age of 30.99. The study population was classified into three groups: gingivitis, chronic periodontitis and aggressive periodontitis. Subjects with aggressive periodontitis were fu...

Background: Chronic periodontitis causes systemic inflammation and increases C-reactive protein (CRP). CRP has been implicated as a possible mediator of associating periodontitis and several systemic diseases. The aim of the present study was to investigate systemic levels of CRP in patients with chronic periodontitis in comparison to periodontally healthy individuals.    Materials and methods:...

OBJECTIVE To evaluate the effects of psychological stress on periodontitis healing in rats and the contribution of basic fibroblast growth factor (bFGF) expression to the healing process. METHODS Ninety-six rats were randomly distributed into control group, periodontitis group, and periodontitis plus stress group. Then, the rats were sacrificed at baseline and week(s) 1, 2, and 4. The periodo...

Periodontitis is a highly prevalent polymicrobial disease worldwide, yet the synergistic pattern of the multiple oral pathogens involved is still poorly characterized. Here, saliva, supragingival and subgingival plaque samples from periodontitis patients and periodontally healthy volunteers were collected and profiled with 16S rRNA gene pyrosequencing. Different oral habitats harbored significa...