The effects of dexamethasone and 20% mannitol infusion in reducing raised intracranial pressure were assessed in severely asphyxiated newborn infants. Intracranial pressure was measured continuously by a percutaneously placed subarachnoid catheter, and cerebral perfusion pressure was calculated from this and blood pressure data. Dexamethasone treatment, assessed in seven infants, produced an ov...

BACKGROUND INTRODUCTION: Birth Asphyxia (Perinatal Asphyxia) in newborn is a condition caused by the inadequate supply of oxygen before, during, or just after birth. Kidney most damaged organ asphyxiated full-term infants. Theophylline considered to be effective as adenosine antagonist reducing renal injury related birth asphyxia OBJECTIVE: To determine mean serum creatinine and glomerular filt...

It is not possible to identify all pregnancies at risk of neonatal hypoxic-ischemic encephalopathy (HIE). Many women use some form of analgesia during childbirth and some anesthetic agents have been shown to be neuroprotective when used as analgesics at subanesthetic concentrations. In this study we sought to understand the effects of two anesthetic agents with presumptive analgesic activity an...

Using conventional criteria, a series of 26 infants was selected for intrapartum asphyxia from about 4000 deliveries over one year at a single hospital to assess the efficacy of a new biochemical method. Tissue damage was estimated from urinary excretion of hypoxanthine, an important and central intermediate in purine metabolism. The overall pattern showed agreement between the grading (by prev...

Perinatal asphyxia (PA) affects the synaptic function and morphological organization. In previous works, we have shown neuronal and synaptic changes in rat neostriatum subjected to hypoxia leading to long-term ubi-protein accumulation. Since F-actin is highly concentrated in dendritic spines, modifications in its organization could be related with alterations induced by hypoxia in the central n...

To identify the main causes of neonatal morbidity and mortality a retrospective study was carried out at the Special Care Baby Unit (SCABU) of the Department of Paediatrics, Bangladesh Institute of Research and Rehabilitation for Diabetes, Endocrine and Metabolic Disorders (BIRDEM) for a period of 1 year from January to December 2005. A total of 361 neonates were included in this cohort. The ra...

OBJECTIVE To determine the risk factors and outcomes of retinopathy of prematurity (ROP) in infants with a birth weight of 1,501-2,000 g. MATERIALS AND METHODS Clinical characteristics and risk factors were compared and nonconditional logistic regression analysis was performed to determine independent predictors for ROP. RESULTS There were 54 (9.8%) cases of ROP in 553 patients with a birth...

Neonatal adrenal hemorrhage is frequently associated with birth trauma, perinatal asphyxia, intrauterine infection, coagulation defects and thromboembolism. It has varied clinical presentation depending on degree of hemorrhage and amount of adrenal cortex compromised by hemorrhage. The most common clinical presentations are persistent jaundice and flank mass. We report a case of left sided adre...

The current study was conducted to correlate the level of DNA damage with multiorgan dysfunction (MOD) in perinatal asphyxia. Among the 80 cases with MOD, 25% each of the babies had five and four organ system involvement , while 23.8% of babies had involvement of 3 systems and 26.3% had 2 organ system dysfunction. The DNA damage increased with the number of systems involved. The comet tail leng...

Background: Functional neuroimaging can provide pathophysiological information in perinatal asphyxia (PA). However, fundamental unresolved questions remain related to the influence of neurovascular coupling (NVC) maturation on functional responses early development. We aimed probe feasibility and compare multiple sensory stimulations newborns with PA using magnetic resonance imaging (fMRI) near...