Background and Purpose—Perfusion-weighted imaging maps are used to identify critical hypoperfusion in acute stroke. However, quantification of perfusion may depend on the choice of the arterial input function (AIF). Using quantitative positron emission tomography we evaluated the influence of the AIF location on maps of absolute and relative perfusion-weighted imaging to detect penumbral flow (...

Dynamic contrast-enhanced MRI of the breast (DCE-MRI) is widely used for detection and quantification purposes of breast cancer. The particular acquisition procedure of DCE-MRI over time leads to motion artifacts which distort analysis results. In this work we examine two criteria for a segmentation approach to separate areas affected by motion artifacts from properly perfused regions. By appli...

Cerebral blood flow (CBF) is the most common parameter for the quantification of brain's function. Literature data indicate a widespread dispersion of values that might be related to some differences in the measurement conditions that are not properly taken into account in CBF evaluation. Using recent high-resolution imaging of the complete cortical microvasculature of primate brain, we perform...