background despite the similar rate of hp infection, the rate of gastric cancer (gc) differs in different regions of the country. there are conflicting reports for using a panel of serologic tests such as pepsinogens i, ii (pg i and pg ii), and gastrin for population screening. we designed this study to assess healthy appearing adults in shiraz, southern iran in order to evaluate the correlatio...

background: currently, non-invasive methods for screening atrophic gastritis and gastric cancer are lacking. the purpose of this study was to evaluate the value of serological parameters including serum pepsinogen i (pgi), pepsinogen ii (pgii) and pepsinogen i: ii ratio for the screening atrophic gastritis and gastric cancer.   methods : the study population consisted of 132 dyspeptic patients ...

alcium just got a promotion. Findings by Caroppo et al. (page 111) reveal that in addition to its many roles inside the cell, Ca 2 ϩ has a distinct extracellular purpose: it acts via a Ca 2 ϩ receptor (CaR) to regulate the function of gastric epithelial cells. It has been known for some time that extracellular Ca 2 ϩ can be sensed by the CaR. The team noted that a Ca 2 ϩ gradient was generated ...

Na-K-2Cl cotransporter-1 (NKCC) has been detected at exceptionally high levels in the gastric mucosa of several species, prompting speculation that it plays important roles in gastric secretion. To investigate this possibility, we 1) immunolocalized NKCC protein in the mouse gastric mucosa, 2) compared the volume and composition of gastric fluid from NKCC-deficient mice and their normal litterm...

Morphological and functional heterogeneity of parietal cells has been thought to be due to different maturation positions within the gastric gland. Morphodynamic studies have shown that 2% of parietal cells in mice derive from a pre-neck (chief) cell precursor. Intrinsic factor (IF) and pepsinogen, markers of rat chief cells, were used to determine if these proteins identified a subset of parie...