JUSTIFICATION There is a need to review/revise recommendations about existing vaccines in light of recent developments in the field of vaccinology. PROCESS Following an IAP ACVIP meeting on April 19 and 20, 2014, a draft of revised recommendations for the year 2014 and updates on certain vaccine formulations was prepared and circulated among the meeting participants to arrive at a consensus. ...

Rotavirus vaccines are highly effective at preventing gastroenteritis in young children and are now universally recommended for infants in the US. We studied patterns of use of rotavirus vaccines among US infants with commercial insurance. We identified a large cohort of infants in the MarketScan Research Databases, 2006-2010. The analysis was restricted to infants residing in states without st...

Background: The sickle gene confers an increased vulnerability to infection, particularly to certain bacterial pathogens, and this has significantly contributed to morbidity and mortality in individuals with sickle cell disease. Immunization plays an important role in the prevention of infection in children with sickle cell disease; we sought to assess the pneumococcal vaccination rate of child...

Let Γ be a graph and let G be a group of automorphisms of Γ. The graph Γ is called G-normal if G is normal in the automorphism group of Γ. Let T be a finite non-abelian simple group and let G = T l with l ≥ 1. In this paper we prove that if every connected pentavalent symmetric T -vertex-transitive graph is T -normal, then every connected pentavalent symmetric G-vertex-transitive graph is G-nor...

Botulism is a potentially lethal disease caused by one of seven homologous neurotoxic proteins usually produced by the bacterium, Clostridium botulinum. This neuromuscular disorder occurs through an exquisite series of molecular events, ultimately ending with the arrest of acetylcholine release and hence, flaccid paralysis. The development of vaccines that protect against botulism dates back to...

A pentavalent rotavirus vaccine for infants became available in the United States in February 2006. By 2007, vaccination rates nationwide were estimated to be approximately 50%. We studied the effectiveness of the vaccine in a real-world setting outside of a clinical trial. All children presenting to The Children's Hospital of Philadelphia with acute gastroenteritis have been monitored for the ...