The mutations present in the spike protein of omicron, a new variant SARS CoV2 favours high transmission Covid fection. To control rate infection finding an effective alternative drug can be beneficial. In our work, we have repurposed 1930 FDA approved drugs which best top five lead compounds based on their GOLD score are Telotris tetethyl, Oxyglutatione, Pentamidinium, Clindamycin palmitate, P...

Interaction between epidermal growth factor (EGF) and gastrin on DNA synthesis of the rat gastrointestinal tract was examined. Fasted male rats were divided into four groups and injected with 10 μg/kg human EGF, 300 μg/kg pentagastrin, human EGF plus pentagastrin and saline (control), respectively. The animals were sacrificed 8 or 16 hr thereafter and the incorporation of [H]thymidine into the ...

The incidence of peptic ulceration in a personal series of 300 patients with Crohn's disease was 8%. Resection of 60 or more centimetres of the small intestine was associated with significantly increased acid output, both basally and following pentagastrin stimulation. Only five (4%) of the 124 patients who received steroid steroid therapy developed peptic ulceration. It is suggested that resec...

The influence of the vagal nerve on the inhibitory effect of neurotensin on pentagastrin stimulated gastric acid secretion was investigated in seven duodenal ulcer patients before and after parietal cell vagotomy without drainage. Preoperatively, neurotensin inhibited gastric acid secretion, whereas no effect was found postoperatively. Plasma concentration of neurotensin was identical pre-and p...

In groups of Chinese patients with duodenal ulcer and controls, increasing the dose of pentagastrin from the standard dose of 6 ug/kg to either 9 ug/kg or 12 ug/kg did not result in any change in the maximum acid output (MAO). Comparison of the MAO thus obtained with that reported in series of Occidental subjects suggested that the Chinese subjects had smaller MAO. Using the method of Card and ...

introduction: the effect of esophageal distension (ed) on gastric motility has been well documented, but a few investigations have been carried out on the effect of ed on gastric secretion. the aim of this study was to investigate the effect of ed on gastric acid and pepsin secretion and the mechanism(s) involved. methods: male adult wistar rats (200-240 g) were anesthetized with urethane (1.2 ...

Introduction: The effect of esophageal distension (ED) on gastric motility has been well documented, but a few investigations have been carried out on the effect of ED on gastric secretion. The aim of this study was to investigate the effect of ED on gastric acid and pepsin secretion and the mechanism(s) involved. Methods: Male adult Wistar rats (200-240 g) were anesthetized with urethane (1...