OBJECTIVES To assess the efficacy of dust respirators in preventing asthma attacks in patients with occupational asthma (asthma induced by buckwheat flour or wheat flour). METHODS The effect of the work environment was examined in two patients with occupational asthma with and without the use of a commercially available mask or a dust respirator. Pulmonary function tests were performed immedi...

The efficacy and tolerability of salmeterol, 50 micrograms b.i.d. was compared for three months with salbutamol, 200 micrograms q.i.d., administered from metered-dose inhaler. For the following nine months, safety and clinic lung function was monitored on salmeterol, 50 micrograms b.i.d., compared with salbutamol, 200 micrograms b.i.d. This comparison was made in a multicentre, double-blind, pa...

A randomised double-blind controlled trial was conducted in order to compare pulmonary function and protective effects of salbutamol 200 micrograms v. 1,000 micrograms by inhalation. Twenty-three known asthmatics took part in the study for a period of 12 weeks. Pulmonary function tests were performed at home (peak expiratory flow-rate (PEFR)) and in the laboratory (vital capacity (VC), forced e...

In a double-blind, cross-over study, 9 children (7-13 yrs old) with stable, moderate asthma inhaled formoterol (6, 18 and 54 micrograms) and salbutamol (100, 300 and 900 micrograms) at hourly intervals, in order to compare the peak effect of cumulative doses of the two drugs. One hour after the last dose, 1 mg salbutamol was inhaled to ensure that maximum bronchodilatation was obtained. The for...

BACKGROUND The safety of sputum induction (SI) is well described in stable asthma, but the safety of SI in exercise-induced bronchoconstriction (EIB) has not been established. OBJECTIVES Our goals were to examine the relationship between the severity of EIB and bronchoconstriction during SI, and to determine if SI conducted after exercise challenge increases the risk of excess bronchoconstric...

Exercise-induced asthma (EIA) is one of the major factors that affect optimal performance in sport. The prevalence of EIA is reported to be on the increase among school children worldwide. The aim of this study was to indicate EIA prevalence among primary-school children in South Africa. A field study determined the prevalence of EIA. A convenience sample of 127 children aged 8 to 16 years was ...

It has been suggested that the use of a cumulative technique to obtain bronchodilator dose-response curves will cause a greater response than a non-cumulative technique, because sequential doses of drug will penetrate further into the lung. To test this hypothesis we have compared cumulative and non-cumulative dose-response curves for inhaled isoprenaline in 10 subjects with stable asthma, meas...

In 11 asthmatic subjects the relative magnitude and the site of airway bronchoconstriction were compared after the oral administration of 40 mg of propranolol and 2.5 mg of pindolol and the magnitude and site of bronchodilation produced by 0.5 mg subcutaneous terbutaline were tested after pretreatment with propranolol and pindolol. Specific airway conductance (sGaw) and peak expiratory flow rat...

this study represents an attempt to determine the prevalence of exercise-induced bronchospasm among soccer player children. a total of 234 soccer player boys of all soccer schools from shahr-rey enrolled in this study. they did not have any history of a recent or chronic respiratory tract disease, a history of allergic diseases, and history of bronchodilator drugs consumption during the 24 hour...

Airway clearance is integral to the management of COPD, yet there is no evidence as to the optimal modality. This study was conducted to compare the efficacy of two chest clearance techniques, autogenic drainage and active cycle breathing in COPD patients.Thirty subjects who were 40 60 years of age and had moderate chronic obstructive pulmonary disorder were allocated randomly into three groups...