BACKGROUND Usual treatment regimens with vancomycin often fail to provide adequate serum levels in patients with severe infections. METHODS Retrospective analysis of vancomycin trough serum measurements. The following parameters were calculated by Bayesian analysis: vancomycin clearance, distribution volume, and peak estimated concentrations. The area under the concentration curve (AUC) (tota...

BACKGROUND The introduction of monoclonal antibodies, either as native molecules or conjugated to radioisotopes or other toxins, has led to new therapeutic options for patients with hematologic malignancies. In addition, the use of small molecules against specific cell surface receptors, enzymes, and proteins has become an important strategy in the treatment of such disorders. METHODS The aut...

metabolic alkalosis is characterized by high hco3- as it is seen in chronic respiratory acidosis, but ph differentiates the two disorders. there is no characteristic symptom or sign. orthostatic hypotension may be encountered. weakness and hyporeflexia occur if serum k+ is markerdly low. tetany and neuromuscular irritability occur rarely. we report the results of retrospective data analysis of ...

Background Chronic liver diseases (CLD) in children represent a growing health problem with significant morbidity and mortality. This study aimed to define the clinicopathological pattern of pediatric CLD in Sohag University Hospital, Sohag,Upper Egypt. Materials and Methods A total of 151children with CLD were included in a prospective hospital-based study from June 2014 to May 2018. Cases of...

BACKGROUND Stroke and sleep-related breathing disorders are both common and are associated with significant morbidity and mortality. Several recent large epidemiological studies have shown a strong association between these 2 disorders independent of known risk factors for stroke. This article will outline the scientific basis for this relationship and suggest sleep-related breathing disorders ...