Monoclonal gammopathies comprise a group of disorders characterized by the neoplastic proliferation of a single clone of plasma cells. Multiple myeloma (MM; plasma-cell myeloma, myelomatosis, Kahler’s disease) is the prototype of monoclonal plasma cell disorders, accounting for 1% of all newly diagnosed cancers and 10% of all hematologic malignancies. It is the second most frequent hematologic ...

haematologica/the hematology journal | 2007; 92(12) | 1589 | Bor T-lymphocyte-mediated autoimmune disorders may lead to clinical disease characterized by low blood cell counts. The term autoimmune cytopenias has been collectively applied to this heterogeneous group of disorders. After the introduction of the humanized, chimeric monoclonal anti-CD20 antibody, rituximab, as a powerful therapeutic...

purpose : to evaluate the efficacy of autologous plasmin in pediatric vitrectomy and to report the anatomic outcomes of autologous plasmin assisted pediatric vitrectomy methods : in an interventional prospective study, thirty-four pediatric patients with vitreoretinal disorders who needed vitrectomy during 2008 to 2010, included in the study. the patients were divided into two groups: the retin...

At the time of writing, five anti-CD19 CAR T-cell products are approved by U.S. Food and Drug Administration for seven different indications in lymphoid malignancies, including B-cell non-Hodgkin lymphoma, pediatric acute lymphoblastic leukemia, multiple myeloma. T cells chronic lymphocytic myeloid less common malignancies such as lymphomas Hodgkin lymphoma being tested early-phase clinical tri...

Autoimmune neutropenia (AIN), resulting from granulocyte-specific autoantibodies, is much less frequent than other autoimmune hematologic disorders including autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). These autoimmune disorders may precede, synchronize, or follow collagen disorders, viral infections, and lymphoid neoplasms. Herein we present the first case of AIN in a...

BACKGROUND Benzene is a widely distributed environmental contaminant known to cause leukemia, particularly acute nonlymphocytic leukemia, and perhaps other hematologic neoplasms and disorders. Few epidemiologic studies, however, have been able to address relationships between the extent of benzene exposure and the level of risk. PURPOSE A large cohort study was carried out in China to evaluat...

Objective. Drugs can induce almost the entire spectrum of hematologic disorders, affecting white cells, red cells, platelets, and the coagulation system. This paper aims to emphasize the broad range of drug-induced hematological syndromes and to highlight some of the newer drugs and syndromes. Methods. Medline literature on drug-induced hematologic syndromes was reviewed. Most reports and revie...