Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset autosomal dominant Parkinson's disease (PD), and sequence variations at the LRRK2 locus are associated with increased risk for sporadic PD. LRRK2 contains both GTPase and kinase domains flanked by protein interaction motifs, and mutations associated with familial PD have been described for both catalytic domains. LRRK2 ...

Numerous studies have confirmed beneficial effects of polyglucose dialysis solution (PG-DS), an amino acid dialysis solution (AA-DS), and bicarbonate (bic) or bicarbonate/lactate (bic/lac) buffered solutions on selected components of peritoneal bioavailability or clinical parameters of peritoneal dialysis (PD) patients. Few adverse effects have also been described. A question arises whether the...

Peritoneal dialysis (PD) is a highly effective and convenient mode of renal replacement therapy. The success of PD depends on maintaining the structural and functional integrity of the peritoneal membrane. The outer (serosal) part of the peritoneal membrane consists of a monolayer of mesothelial cells, which provide a low-friction surface, allowing internal organs to move relative to one anothe...

Pd nanoparticles were well dispersed on a new triptycene-based microporous polymer support by the gas bubbling-assisted membrane reduction (GBMR) method. The stability of Pd nanoparticles is improved by the porous support, and the materials show excellent performance for CO oxidation.

The use of peritoneal dialysis (PD) has become wide spread since the introduction of continuous ambulatory PD more than 25 years ago. Over this time, many advances have been made and PD is an alternative to hemodialysis (HD), with excellent comparable survival, lower cost, and improved quality of life. The percentage of prevalent PD patients in the United States is approximately 7%, which is si...

Aberrant protein glycosylation plays major roles in neurodegenerative diseases, including Parkinson's disease (PD). Glycoproteomics showed that the glycosylation of sodium channel β4 was significantly increased in human brain tissue. β4-specific antibodies reacted in immunoblot assays with the 35- and 38-kDa bands from the membrane fractions isolated from neonatal PD transgenic mice but only wi...

Mixed matrix membranes (MMMs) are attracting significant interest for pervaporation and gas separation applications. To better comprehend the impact of filler particles within polymer matrices, the species permeation mass transport was theoretically studied by numerical simulation using finite differences. The Fick’s second law of diffusion was solved for a three-dimensional MMM to obtain the c...

Plasmodesmata (PD) connect neighboring plant cells and establish cytoplasmic and membrane continuity throughout most of the plant. Since callose at the neck region of PD regulates plasmodesmatal permeability (De Storme and Geelen, 2014), much research has focused on identifying proteins that affect callose turnover and stability at PD. For instance, the PD callose binding proteins (PDCBs), a fa...

Parkinson’s disease (PD) is the second most common neurodegenerative disease, affecting six million people worldwide. It results from the specific loss of substantia nigra dopaminergic neurons, which accumulate large filamentous structures called Lewy bodies composed mostly of one misfolded and aggregated protein called -synuclein. The aggregation and membrane phospholipid binding ability of -s...