Microfluidic technologies have recently been shown to hold significant potential as novel tools for producing micro- and nano-scale structures for a variety of applications in tissue engineering and cell biology. Over the last decade, microfluidic spinning has emerged as an advanced method for fabricating fibers with diverse shapes and sizes without the use of complicated devices or facilities....

Abstract Multifunctional fiber mats are explored as potential bioactive matrices for the development of next generation guided bone regeneration membranes with tunable microstructure, strength and therapeutic activity. In present study, polycaprolactone (PCL) nanofibers different concentrations ascorbic acid derivatives (ascorbyl palmitate) strontium polyphosphate nanoparticles (Sr-polyP NPs) w...

The objective of this paper was to fabricate a biodegradable tubular scaffold for small diameter (d<6 mm) blood vessel tissue engineering. The tube scaffold needed a porous wall for cell attachment, proliferation and tissue regeneration with its degradation. A novel method given in this paper was to coat a porous layer of poly (epsilon-caprolactone) (PCL) on the outside of a poly (glycolic-co-l...

BACKGROUND AND OBJECTIVES In this in vitro feasibility study we analyzed tissue fusion using bovine serum albumin (BSA) and Indocyanine green (ICG) doped polycaprolactone (PCL) scaffolds in combination with a diode laser as energy source while focusing on the influence of irradiation power and albumin concentration on the resulting tensile strength and induced tissue damage. MATERIALS AND MET...

Polycaprolactone (PCL) is being developed as the material of scaffolds for tissue engineering [1]. PCL is considered having fair mechanical properties and characteristics of potentials for load bearing applications, including cardiovascular, dental, and musculoskeletal [1-4]. Yet, its implementation faces some issues, e.g. inadequate mechanical properties, bioresorbability, and hydrophilicity [...

We have developed a method to create longitudinally oriented channels within poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogels for neural tissue engineering applications. Incorporated into an entubulation strategy, these scaffolds have the potential to enhance nerve regeneration after transection injuries of either the spinal cord or the peripheral nerve by increasing the available surface ar...

Poly (ε-caprolactone), (PCL) or simply polycaprolactone as it is usually referred to, is a synthetic biodegradable aliphatic polyester which has attracted considerable attention in recent years, notably in the biomedical areas of controlled-release drug delivery systems, absorbable surgical sutures, nerve guides, and three-dimensional (3-D) scaffolds, for use in tissue engineering. Various poly...

Smart antibacterial materials capable of releasing antibiotic drugs upon exposure to external triggers are highly desired for various medical applications. Herein, the fabrication thermosensitive drug-loaded core−shell nanofibers using electrospinning technique combined with in situ UV photopolymerization is reported on. The method used shaping core structure comprising biodegradable polymer po...

We developed a dynamic cell culture platform with dynamically tunable nano-roughness and elasticity. Temperature-responsive poly(ε-caprolactone) (PCL) films were successfully prepared by crosslinking linear and tetra-branched PCL macromonomers. By optimizing the mixing ratios, the crystal-amorphous transition temperature (Tm) of the crosslinked film was adjusted to the biological relevant tempe...

Polymers in nanofibrous forms offer new opportunities for achieving triggered polymer degradation, which is important functional and environmental reasons. The polycaprolactone (PCL) nonwoven webs developed this work by solution blow spinning with entrapped enzymes were completely, rapidly controllably degraded when exposure to water. Lipase (CALB) from Candida antarctica was successfully the P...