enable ordinary end users to create programs without needing to learn the arcane details of programming languages, but simply by demonstrating what their program should do. If PBD were successful, the vast population of nonprogrammer computer users would be able to take control of their computing experience and create programs to automate routine tasks, develop applications for their specific n...

Current patterns of biodiversity distribution result from a combination of historical and contemporary processes. Here, we compiled checklists of amphibian species to assess the roles of long-term climate stability (Quaternary oscillations), contemporary environmental gradients and geographical distance as determinants of change in amphibian taxonomic and phylogenetic composition in the Brazili...

The Polo-Like Kinase 1 (PLK1) acts as a central regulator of mitosis and is over-expressed in a wide range of human tumours where high levels of expression correlate with a poor prognosis. PLK1 comprises two structural elements, a kinase domain and a polo-box domain (PBD). The PBD binds phosphorylated substrates to control substrate phosphorylation by the kinase domain. Although the PBD prefere...

The question of the need for routine preoperative drainage biliary tree in peripapillary tumor obstruction is still debatable. We conducted a retrospective randomized single–center study, first control point which was to study safety percutaneous drainage, second effect on number postoperative complications pancreatoduodenectomy (PD). results 85 Whipple’s PD head pancreas were analyzed. Preoper...

The degradation mechanism of phosphorescent-dye-doped polymer light-emitting diodes ~PLEDs! is investigated. The active medium of our PLED is a polymer blend comprising poly~vinylcarbazole! ~PVK!, @2-~4-biphenylyl!-5-~4-tert-butyl-phenyl!-1,3,4-oxadiazole# ~t-PBD!, and platinum~II!-2,8,12,17-tetraethyl-3,7,13,18-tetramethylporphyrin ~PtOX!. The cyclic voltammetry result shows that the reductive...

Members of polo-like kinases (collectively, Plks) have been identified in various eukaryotic organisms and play pivotal roles in cell proliferation. They are characterized by the presence of a distinct region of homology in the C-terminal noncatalytic domain, called polo-box domain (PBD). Among them, Plk1 and its functional homologs in other organisms have been best characterized because of its...

We present a visual language that serves as a novel form of feedback in a Programming by Demonstration (PBD) interface. The language explicitly represents data, such as les, with unique icons and implicitly represents operations by changes to data icons, so that operations reeect the changes seen in the interface when executed. In addition, the language is used to provide feedback to the user b...

The polo-box domain (PBD) of mammalian polo-like kinase 1 (Plk1) is essential in targeting its catalytic activity to specific subcellular structures critical for mitosis. The mechanism underlying Plk1 recruitment to the kinetochores and the role of Plk1 at this site remain elusive. Here, we demonstrate that a PBD-binding protein, PBIP1, is crucial for recruiting Plk1 to the interphase and mitot...

OBJECTIVE Research on neurocognitive impairment in adult patients with comorbid bipolar disorder (BD) and attention-deficit hyperactivity disorder (ADHD) is very scarce. This study assessed the neurocognitive profile of a comorbid group (BD+ADHD) compared with that of pure BD (pBD) group, pure ADHD (pADHD) group and healthy controls (HCs). METHODS This was a three-site study comprising 229 su...

The polo-box domain (PBD) has critical roles in the mitotic functions of polo-like kinase 1 (PLK1). The replacement with partial ligand alternative through computational enrichment (REPLACE) strategy to develop inhibitors of protein–protein interactions has identified alternatives for the N-terminal tripeptide of a Cdc25C substrate. In addition, a peptide structure–activity relationship describ...