Background: Lymphoma is a malignant proliferation of lymphoid cells. External T-cell lymphoma is very rare. Lymphomas are neoplastic growth of lymphocytes caused by organisms like EBV, HIV, etc. This malignancy is classified as Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. Oral lymphomas account for a small percentage of head and neck malignancies, and intraoral lymphoma is rare and mostly see...

BACKGROUND Exaggerated reaction to insect bites, mainly to mosquitoes, is infrequently described in patients with chronic lymphocytic leukemia. Skin lesions usually appear months to years after the diagnosis of leukemia and are unrelated to laboratory findings, disease course, or therapy. OBSERVATIONS We describe 8 patients with various hematologic disorders (chronic lymphocytic leukemia, acu...

burkitt's lymphoma is a lymphatic tumor classified as non-hodgkin lymphoma with small non cleaved cells. the disease has an incidence of two cases per million patients in north america, and usually present with an intra-abdominal tumor, or enlarged cervical lymph nodes. massive amounts of peritoneal and plural fluid is rarely seen in these patients. a three year-old girl presented with massive ...

Primary myeloid sacrom (MS) is a rare tumor and even more rare in multiple organs with no evidence of bone marrow involvement. This report describes an unusual case of a 19-year-old male presenting scrotal MS with a history of subconjunctival MS, 5 months ago. Bone marrow biopsies showed no evidence of acute leukemia. Despite radiotherapy for first involvement and chemotherapy for second presen...

BACKGROUND Although no definite risk factors have emerged for the different hematological malignancies, a viral cause has been postulated. Several studies have detected SV40 DNA sequences in tumor tissues obtained from non-Hodgkin's lymphoma patients. A link between SV40 and NHL is biologically plausible because SV40 causes hematological malignancies in laboratory rodents. METHODS We investig...

Children with neurofibromatosis type 1 (NF1) are predisposed to malignancies such as brain tumors, leukemia, and pheochromocytomas. The aim of this study was to evaluate malignancy in patients with NF1. We studied 120 patients with NF1 in this study. Demographic data from these patients were retrospectively reviewed. We found 20 malignancies in 19 patients in our study. Ten children with NF1 ha...

Introduction: Patients (pts) with primary refractory or relapsed Burkitt lymphoma/leukemia (BL) high-grade B-cell lymphoma MYC and BCL2 rearrangements (double hit, DHL) and/or BCL6 (triple THL) have a dismal prognosis. A dysregulated oncogene has downstream effects on proliferation highly glycolytic metabolism tricarboxylic acid (TCA) cycle intermediates as biosynthetic precursors. Devimistat i...