background: the pattern of drug abuse in iran has dramatically changed in recent years, turning from the traditional opioids [opium, opium dross, and refined opium dross (shireh)] into drugs with newer forms. the present study is aimed at investigating the frequency of pathological changes in the lungs of bodies with positive postmortem toxicology results for narcotics and psychotropic substanc...

Cognitive abilities rise steeply from infancy to young adulthood and then are either maintained or decline to old age, depending on the specific ability. This pattern suggests corresponding continuities of mechanism and process, but it is striking that the fields of cognitive development and cognitive aging make little contact with each other's methods and theories. In this review we examine re...

The prospects for effectively treating well-established dementia, such as Alzheimer's disease (AD), are slim, due to the destruction of key brain pathways that underlie higher cognitive function. There has been a substantial shift in the field towards detecting conditions such as AD in their earliest stages, which would allow preventative or therapeutic approaches to substantially reduce risk a...

In response to stress, cells rapidly produce a series of new proteins known as heat shock proteins (HSP). HSPs are considered to be molecular chaperones which play a universal role in maintaining cellular homeostasis. It is known that different HSPs are expressed in skeletal muscle, namely, small HSPs (including ubiquitin, alpha B- crystallin, HSP20 and HSP 27), HSP70, HSP60 and HSP90. Skeletal...

Chronic bronchitis defies close definition, just as it has defied all attempts at prevention or cure. Its beginning is innocuous enough, being characterized by cough and clear mucoid sputum; yet this may lead to incapacitating breathlessness, heart failure and death. Pathologically the disease is disappointing in that there is no specific or diagnostic lesion, since in its early or mild stage t...

Multiple system atrophy (MSA) is a rare neurodegenerative disorder associated with parkinsonism, ataxia, and autonomic dysfunction. Its pathology is primarily subcortical comprising vacuolation, neuronal loss, gliosis, and α-synucleinimmunoreactive glial cytoplasmic inclusions (GCI). To quantify cerebellar pathology in MSA, the density and spatial pattern of the pathological changes were studie...

Increasing trend of poisoning in rural as well as urban set up for committing suicides must drive attention of law enforcing agencies to restrict its use and providing better methods for pest control. One of the organs suffered by such poisoning is liver, which is studied in detail in this study with special reference to histopathological finding. Out of total 140 autopsies 78 cases revealed hi...

We studied the developmental trends of temperament and character in a longitudinal population-based sample of Finnish men and women aged 20-45 years using the Temperament and Character Inventory model of personality. Personality was assessed in 1997, 2001, and 2007 (n = 2,104, 2,095, and 2,056, respectively). Mean-level changes demonstrated qualitatively distinct developmental patterns for char...