Several randomized and observational studies have reported steady increase in cumulative incidence of late and very late ST (LST/VLST) following first-generation drug-eluting stents (DES: sirolimus-(SES) and paclitaxel-(PES)) up to 5 years. Pathologic studies have identified uncovered struts as the primary substrate responsible for LST/VLST following DES, where delayed arterial healing is assoc...

BACKGROUND Radiotherapy (XRT) exerts detrimental collateral effects on bone tissue through mechanisms of vascular damage and impediments to osteocytes, ultimately predisposing patients to the debilitating problems of late pathologic fractures and nonunions. We posit that angiogenic therapy will reverse these pathologic effects in a rat model of radiated fracture healing. METHODS Three groups ...

conclusions psa, psa density, and gleason score should be considered together in order to more accurately predict the adverse pathologic features of prostate cancer. methods we conducted a cross-sectional study of 105 patients with localized prostate cancer who underwent radical prostatectomy between 2006 and 2013. we recorded gleason scores and psa levels, in addition to the results of patholo...

Thirteen long Gamma nails were utilized without adjunctive bone cement in 11 patients for stabilization of 12 impending pathologic fractures and 1 pathologic fracture in the setting of metastatic disease (10 femora) and fibrous dysplasia (3 femora) of the proximal femur. Each femur was reamed to 18 mm proximally and 13 mm distally to accept the 17-mm diameter proximal portion and the 11-mm dist...

Background: Paragangliomas (PGLs) are neuroendocrine tumors that arise from the neuroepithelial cell group called paraganglia. Spinal paragangliomas (SPs) are extremely rare, most of which are observed as intradural tumors in the cauda equine, the filum terminale, and the lumbosacral region, but rarely in the thoracic region. We aimed to study the clinical, radiographic and pathologic character...

One of the main goals in fracture treatment is reservation of both intramedular and periosteal vascularisation. The aim of this paper is to show a new method of internal fixation which accomplishes these goals. The paper presents the results of clinical application of Mitkovic Internal Fixator, new self-dynamisable device, which provides fixation of the femur using minimally invasive technique....

Background/introduction Osteoid osteoma (OO), a small painful benign bone tumor, is the most common bone tumor in children. Pain is managed with nonsteroidal anti-inflammatory drugs but minimally invasive techniques, such as CT-guided laser ablation, have become a standard intervention. However, the potential for non-target injury is a concern as tissue temperature cannot be measured with CT an...