AIM To explore whether acute cellular DNA damage response is induced upon hepatitis B virus (HBV) infection and the effects of the HBV infection. METHODS We incubated HL7702 hepatocytes with HBV-positive serum, mimicking a natural HBV infection process. We used immunoblotting to evaluate protein expression levels in HBV-infected cells or in non-infected cells; immunofluorescence to show ATR f...

BACKGROUND Coinfection with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) is common. Most studies have concentrated on the effects of chronic HIV infection on HBV infection; however, studies on the effects of acute HIV infection on HBV infection are especially important to elucidate the potential mechanisms leading to complications from HIV/HBV coinfection. METHODS We evaluat...

Background and Aim: Occult hepatitis B virus (HBV) infection is an incompletely understood condition. There no data about occult HBV in sero-discordant couples. We attempted to find out the prevalence of OBI this cohort formulate guidelines for vaccination. Methods: 40 couples were enrolled. DNA (quantitative), Anti HBc HBs titre (quantitative) done. was defined as positivity without detectable...

objective: occult hepatitis b infection is a form of hepatitis in which despite of absence of detectable hbsag, hbv-dna is present in peripheral blood of patients. this clinical form of b hepatitis creates some problems for the iranian blood transfusion services. therefore, the aim of this study was the evaluation of status of occult hepatitis b infection in the rafsanjanese blood donors. mate...

occult hepatitis b (ohb), or persistent hepatitis b virus (hbv) viremia in surface-antigen-hbsag-negative patients, has been recognized as a medical concern during the last decade. the exact magnitude, pathogenesis and clinical relevance of ohb are unclear. this review organizes the published data on ohb and presents an overview of the current hypotheses on ohb's pathogenesis and clinical relev...

Hepatitis B virus (HBV) infection and its sequelae remain a major public health burden, but both HBV basic research and the development of antiviral therapeutics have been hindered by the lack of an efficient in vitro infection system. Recently, sodium taurocholate cotransporting polypeptide (NTCP) has been identified as the HBV receptor. We herein report that we established a NTCP-complemented...

BACKGROUND AND AIMS Chronic infection with the hepatitis B virus (HBV) is a major health issue worldwide. Recently, single nucleotide polymorphisms (SNPs) within the human leukocyte antigen (HLA)-DP locus were identified to be associated with HBV infection in Asian populations. Most significant associations were observed for the A alleles of HLA-DPA1 rs3077 and HLA-DPB1 rs9277535, which conferr...

Hepatitis B Virus (HBV) infection is a major health problem in the developing countries counting Pakistan. This study aimed to examine causes and molecular prevalence of HBV district Bannu Khyber Pakhtunkhwa province,

background: the household transmission of hepatitis b virus (hbv) is a major health problem. high incidence of hbv infection is observed within the household contacts of hbv carriers. we aimed to evaluate serological markers of hepatitis b infection among family members of hbv carriers in arak, central iran. methods: data were collected from the 100 chronic hbv carriers (subjects with positive ...

The present study was designed to assess the risk of hepatitis B virus (HBV) infection among hospital employees, who often contract the infection before the beginning of their employment, and to suggest a prevention strategy. The study population consisted of 2518 subjects working or studying at the two Hadassah University hospitals, on Mount Scopus and at Ein Kerem in Jerusalem. The total prev...