Background and Objective: Diabetes mellitus (DM) in long-term is associated with learning and memory decline. Metformin is an anti-diabetic drug with antioxidant and memory-improving effects. Thus, this research study was conducted to assess the effect of metformin on learning and memory in diabetic rats. Materials and Methods: In the present study, male Wistar rats (n=32) were randomly assign...

Introduction: Zinc is an essential rare element that plays an important role in synaptic plasticity and modulation of the activity of central nervous system and is involved in learning and memory. Increasing zinc intake may protect against conditions associated with zinc deficiency, such as diabetes. Some studies have revealed that zinc deficiency in diabetic subjects is due to hogher excret...

Introduction: The life quality of patients with epileptic seizures is highly affected by cognitive deficits. Low Frequency Stimulation (LFS) is a novel approach for the treatment of pharmacoresistant epilepsy. The main goal of this research is investigating the possible effect of LFS on seizure-induced cognitive dysfunction.  Methods: To this end, the kindled animal were prepared via CA1 ...

The temporally dissociated passive avoidance (TDPA) paradigm is a variant of passive avoidance testing, and allows for more sensitive investigation of mild impairments in avoidance learning. Passive avoidance learning measures the latency to enter a "dark" context in which an aversive stimulus (foot shock) has been previously experienced using a light-dark box paradigm. Briefly, the animal is p...

Background: Progesterone as a reproductive hormone is studied in the brain structure. New studies are mainly about systemic injection and have shown that the progesterone has different effects on memory. But it is not clear if hippocampus is mediator of progesterone in reinforcement of memory and learning. So, the effects of intra-hippocampal injection of progesterone on passive avoidance memor...

stress has a profound impact on the nervous system and causes cognitive problems that are partly related to the inflammatory effects. besides influencing the content of neurotransmitters, antidepressants such as doxepin are likely to have anti-inflammatory, anti-oxidative, and anti-apoptotic effects. therefore, the present study investigated the effects of doxepin on passive avoidance learning ...