Basic helix-loop-helix (bHLH) transcription factors are known as key regulators for mesenchymal differentiation. The present study showed that overexpression of Twist-1, a bHLH transcription factor, suppresses bone morphogenetic protein (BMP)-induced osteoblast differentiation, and downregulation of endogenous Twist-1 enhances BMP signaling. Maximal inhibition of BMP signaling was observed when...

BACKGROUND Epithelial-mesenchymal transition (EMT) is associated with tumor hypoxia. EMT is regulated, in part, by the action of TWIST, which inhibits of E-cadherin expression and may interfere with the p53 tumor-suppressor pathway. METHODS We examined the expression of TWIST, E-cadherin, hypoxia-inducible factor 1α (HIF1α), and p53 by immunohistochemistry in 123 cases of ovarian epithelial c...

Evidence suggests that over-expression of TWIST, an epithelial-mesenchymal transition inducer, might have a correlation with cancer progression and chemoresistance. However, its roles in radioresistance of cancer have rarely been reported. High TWIST expression was detected in nasopharyngeal carcinoma (NPC) and associated with poor prognosis. Thus, in the present study, we aimed to determine wh...

introduction: second national medical sciences olympiad was done in shiraz in august 2010 with aim of indentifying scientifically talented individuals, motivating students and orienting extracurricular activities. this olympiad was done in 3 areas, basic sciences, clinical sciences and management. in clinical sciences, we used tosce (team objective structured clinical examination). in this arti...

bronchial leiomyoma is extremely rare. to date less than 60 cases have been reported in the world literature. the presented case here is a 30 year old woman who had been treated for bronchial asthma for several years. her chest radiograph showed bulluos emphysematous changes in the right lung and computer tomography scan found the tumor in the right main bronchus near carina. diagnosis was made...

background: different studies have shown that inadequate and unbalanced intake of nutrients including micronutrient and macronutrient, have negative effects on exercise performance and optimal ability; besides, it decreases physical efficiency in athletes. the present study aimed to assess the nutritional status and body composition of female athletic students in isfahan university of medical s...

ab initio calculations at hf/6-31g* level of theory for geometry optimization and mp2/6-31g*//hf/6-31g* for a single point total energy calculation are reported for the importantenergy-minimum conformations and transition-state geometries of 1, 3-diazacyclohepta-1, 2-diene (2) and 1, 3-diazacycloocta-1, 2-diene (3). the c2 symmetric twist-chair (2-tc)conformation of 2 is calculated to be 7.4 kj...

Today's economic development has improved land law relations towards an increasingly complex situation. the use of today led to multifunctionality is not as simple when Law No. 5 1960 on agrarian regulations and principles promulgated. Indonesia undergoing a shift stepped era takeoff, only used for agricultural but benefit even become object business thus forms transition rights are diverse com...

Medaka twist, a basic helix-loop-helix (bHLH) transcription factor, is expressed in the sclerotome during embryogenesis. We previously established a line of twist-EGFP transgenic medaka, whose EGFP expression is regulated by the twist promoter; therefore, we could observe the behavior of sclerotomal cells in vivo. In the transgenic medaka embryos, EGFP-positive sclerotomal cells migrated dorsal...

This study aimed to examine HIF-2α, TWIST, and CXCR4 expression in papillary thyroid carcinoma (PTC) and assesses the association of their expression with clinicopathological indicators. HIF-2α, TWIST, and CXCR4 protein expression in 129 PTCs, 61 nodular hyperplasia, and 118 normal thyroid tissue specimens was analyzed using immunohistochemistry. The protein expression levels of these three mol...