Most live-attenuated tetravalent dengue virus vaccines in current clinical trials are produced from Vero cells. In a previous study we demonstrated that an infectious cDNA clone-derived dengue type 4 (DEN-4) virus retains higher genetic stability in MRC-5 cells than in Vero cells. For this study we investigated two DEN-4 viruses: the infectious cDNA clone-derived DEN-4 2A and its derived 3' NCR...

In TREC-5 we used document retrieval based on arbitrary passages [8, 9], or xed-length passages that could start at any word position. Although far from the best runs in TREC5, these results were promising, in particular for long documents. In TREC-6 we continued with arbitrary passages, but our main emphasis was on comprehensive factor analysis of successful automatic query expansion and re ne...

Random amplified polymorphic DNA (RAPD) analysis was adapted for genomic identification of cell cultures and evaluation of DNA stability in cells of different origin at different culture passages. DNA stability was observed in cultures after no more than 5 passages. Adipose-derived stromal cells demonstrated increased DNA instability. RAPD fragments from different cell lines after different num...

Information retrieval (IR) techniques are used in question answering (QA) to retrieve passages from large document collections which are relevant to answering given natural language questions. In this paper we investigate the impact of document segmentation approaches on the retrieval performance of the IR component in our Dutch QA system. In particular we compare segmentations into discourse-b...

We describe a system developed for the Categorization task of the Text Retrieval Conference (TREC) 2005 Genomics track, and experiments we conducted in the process of developing our system. Our research effort for this task explored the hypothesis that more accurate predictions could be achieved by considering only selected passages in the documents being processed. We investigated methods that...

The authors used the computational tool Coh-Metrix to examine expert writers’ paraphrases and in particular, how experts paraphrase text passages using condensing strategies. The overarching goal of this study was to develop machine learning algorithms to aid in the automatic detection of paraphrases and paraphrase types. To this end, three experts were instructed to paraphrase by condensing a ...