BACKGROUND Topical aloe vera (AV) has been used to treat various skin conditions, including psoriasis, with good results. OBJECTIVES This study aims to compare the efficacy of AV and 0.1% triamcinolone acetonide (TA) in mild to moderate plaque psoriasis. METHODS A randomized, comparative, double-blind, 8-week study was designed. Eighty patients randomly received AV or 0.1% TA cream and thei...

Aim of the study : To compare the efficacy and tolerability of various topical therapies like short contact Lipsomal dithranol ointment, 0.1% Betamethasone valerate ointment and liquid paraffin for psoriasis. Materials and Methods: This study was conducted in dermatology department of a tertiary hospital and a total of sixty patients who attended the Psoriasis clinic were randomly allocated to ...

BACKGROUND Chronic plaque-type psoriasis is a major dermatosis, but a significant question is still unanswered: What defines severity in chronic plaque-type psoriasis? While objective assessments like the Psoriasis Area and Severity Index (PASI) have frequently been used in clinical trials, quality of life (QOL) questionnaires are currently becoming more and more popular. OBJECTIVE This artic...

This paper presents a summary of the evidence review group (ERG) report into the clinical and cost-effectiveness of infliximab for the treatment of moderate to severe plaque psoriasis, in accordance with the licensed indication, based on the evidence submission from Schering-Plough to the National Institute for Health and Clinical Excellence (NICE) as part of the single technology appraisal (ST...

Background: Psoriasis is a complex, chronic disease with increasing global incidence. Studies on the effectiveness of psoriasis therapy in Indonesia are limited. This study aimed to evaluate patient’s clinical improvement moderate-to-severe vulgaris using Area and Severity Index ≥75% score reduction (PASI75).
 Methods: retrospective involving patients diagnosed who visited Dermatology Vene...

BACKGROUND Etanercept plus methotrexate combination therapy has not been adequately investigated in psoriasis. OBJECTIVES To evaluate etanercept plus methotrexate vs. etanercept monotherapy in patients with moderate to severe plaque psoriasis who had not failed prior methotrexate or tumour necrosis factor-inhibitor therapy. METHODS Patients received etanercept 50 mg twice weekly for 12 week...

Introduction Herein, we developed an engineered extracellular vehicle (EV)-based method for ameliorating inflammatory responses in psoriasis.Methods EVs, derived from annexin A1 (ANXA1) overexpressing T cells, were co-extruded with M2 macrophage membrane to obtain EVs. In vitro, the effect of EVs on polarization was evaluated by real-time PCR. imiquimod (IMQ)-induced psoriasis-like mouse model,...

BACKGROUND Few studies have directly compared the clinical efficacy of psoralen plus ultraviolet A (PUVA) vs. biologics in the treatment of psoriasis. OBJECTIVES To compare the clinical efficacy of PUVA and biologic therapies for psoriasis under daily life conditions. METHODS Data from a psoriasis registry (http://www.psoriasis-therapieregister.at) of 172 adult patients with moderate to sev...