Hypocalcemia is presented in two forms, the less common clinical disease called milk fever and the more common form called subclinical hypocalcemia (SCH). Depending upon how it is defined and the frequency of blood sampling for diagnosis, SCH can affect 25 to 40% of primiparous and 45 to 80% of the multiparous cows. Cows with SCH have reduced dry matter (DM) intake, suppressed measures of innat...

BACKGROUND The purpose of this study was to determine the effectiveness of oral calcium plus vitamin D supplementation and to compare the effects of cholecalciferol versus calcitriol treatments on postoperative hypocalcemia. METHODS After total thyroidectomy with central neck dissection, 306 patients were divided into 4 groups according to "routine use versus on-demand use" and "cholecalcifer...

HYPOTHESIS Age, postoperative serum parathormone (PTH) level, and preoperative serum 25-hydroxyvitamin D(3) (25-OHD) level predict postoperative hypocalcemia after total thyroidectomy. DESIGN Prospective clinical trial. SETTING Tertiary referral center. PATIENTS One hundred thirty patients with nontoxic multinodular goiter. Patients were divided into 2 groups according to the postoperativ...

N-(3-[2-Chlorophenyl]propyl)-(R)-alpha-methyl-3-methoxybenzylamine (NPS R-568) is an orally active compound that activates Ca(2+) receptors on parathyroid cells and rapidly suppresses plasma levels of parathyroid hormone (PTH) and Ca(2+) (ED(50), 1 and 10 mg/kg, respectively). We now show that increased calcitonin secretion contributes to NPS R-568-induced hypocalcemia. In parathyroidectomized ...

OBJECTIVES To identify any risk factors for incidental parathyroidectomy and to define its association with symptomatic postoperative hypocalcemia. DESIGN Retrospective study. SETTING Tertiary referral cancer center. PATIENTS Consecutive patients who underwent thyroid surgery between 1991 and 1999. Patients who underwent procedures for locally advanced thyroid cancer requiring laryngectom...

Although stridor is a common respiratory symptom associated with upper respiratory diseases, yet its relation with hypocalcemia is not widely appreciated. The mechanism of hypocalcemia in causing stridor might be a collapsing of larynx most likely caused by decalcifi cation due to hypocalcemia. Vitamin D defi ciency causes a reduction in serum calcium, which stimulates the production of extra P...

INTRODUCTION Hypoparathyroidism is an entity associated with hypocalcemia, more frequently a consequence of neck surgery. An autoimmune etiology is rare and its diagnosis difficult to establish. CLINICAL REPORT 52 year-old woman, with irrelevant past medical history and no significant familial conditions, referred because of hypocalcemia and basal ganglia calcifications, detected in the cours...

Familial hypoparathyroidism (also termed autosomal dominant hypocalcemia) is characterized by hypocalcemia, hyperphosphatemia, and relative hypercalciuria, particularly during treatment with vitamin D and calcium to correct the hypocalcemia. Serum parathyroid hormone is inappropriately suppressed. Over 30 activating missense mutations in the calcium-sensing receptor gene have been identified in...

BACKGROUND The risk of hypocalcemia after total thyroidectomy is well-described in the literature. Recalcitrant hypocalcemia after thyroidectomy in a lactating woman is uncommon and may require multiple strategies to correct. METHODS We present a case report of a lactating woman with papillary thyroid carcinoma requiring total thyroidectomy and neck dissections. RESULTS Postoperatively the ...

OBJECTIVE The purpose of this study was to evaluate if the measurement of peri-operative parathyroid hormone (PTH) is able to identify patients with increased risk of developing symptoms of hypocalcemia. SUBJECTS AND METHODS Forty patients who underwent total thyroidectomy were studied prospectively. Ionized serum calcium and PTH were measured after induction of anesthesia, one hour (PTH1) an...