Glioblastoma (GBM) is an aggressive malignancy with a high rate of tumor recurrence after treatment conventional therapies. Parthenolide (PTL), sesquiterpene lactone extracted from the herb Tanacetum parthenium or feverfew, possesses anticancer properties against wide variety solid tumors. In present study, series PTL derivatives were synthesized and screened. An inhibitor, dimethylaminoparthen...
