Modularization of crosscutting concerns is the main benefit provided by Aspect-Oriented constructs. However, it does not address class modularity adequately. In order to assess both class and crosscutting modularity of AO systems, we use Design Structure Matrixes (DSMs) to analyze three different versions (OO, AO, and AO using design rules) of a real software application. We observed that, in t...

Modeling and simulation methods are now commonly used in drug product development and regulatory drug review process. These applications include, but are not limited to: the development of biorelevant specifications, determination of bioequivalence matrixes for modified release products with rapid therapeutic onset, design of in vitro-in vivo correlations in a mechanistic framework, and predict...

This work focuses on the synergetic effect obtained by immobilization of Rhamnus frangula L. (RfL) phytoextract in layered double hydroxides (LDHs) matrixes and their subsequent encapsulation into biocompatible hydrogels (HG). In this respect, LDHs were used as hosts for a reconstruction method, after which LDHsRfL embedded hydrogel (HG) matrixes, based polyethylene glycol diacrylate (PEGDA), r...

This paper presents results on ultralong read DNA sequencing with relatively short separation times using capillary electrophoresis with replaceable polymer matrixes. In previous work, the effectiveness of mixed replaceable solutions of linear polyacrylamide (LPA) was demonstrated, and 1000 bases were routinely obtained in less than 1 h. Substantially longer read lengths have now been achieved ...

An extensive analysis of the conformational space of tryptophan (Trp) was performed at the B3LYP/6-311++G(d,p) level and verified by comparison with the infrared spectra of the compound isolated in low-temperature argon and xenon matrixes. Different types of conformers have been unequivocally identified in the matrixes. Type I exhibits the trans arrangement of the carboxylic group and is stabil...

The work is devoted to obtaining a medium – sized cartridge blank from low-carbon steel. sequence of punching transitions includes hot back- extrusion operation, two cold draw thinning operations, and crimp operation. Modeling using the finite element method established: efforts specific forces during thermal effect shaping, shape size semi finished products with distributions strain intensity....

A new chromatographic method for the determination of oxidants, such as peroxyborates and peroxides, present in a pulp matrix has been developed. The new method is characterized by its high reproducibility, its low limit of detection, and its high selectivity. Thioanisole (methylphenyl sulfide) is shown to selectively and quantitatively react with oxidants that are present within a pulp matrix....