The major salivary glands consist of the parotid, the submandibular, and the sublingual glands. Under the control of the parasympathetic nervous system, the major salivary glands are responsible for the principal portion of saliva produced, which can be as much as 1.5 liters per day. The minor salivary glands of the oral cavity, pharynx, and upper airways contribute only a small percentage of t...

Background. To investigate the relationships among blood glucose, mixed saliva glucose, and parotid glucose in type 2 diabetes patients and to evaluate the diagnostic and monitoring value of salivary gland glucose in patients with type 2 diabetes (type 2DM). Material and Methods. Thirty patients with type 2DM and 30 healthy age- and sex-matched individuals were included in this study. Glucose l...

Previous reports suggested that there is no significant difference in the binding affinity of pilocarpine and cevimeline on muscarinic receptors (1). However, in vivo studies from our laboratory suggested that pilocarpine-induced salivation from the parotid gland is greater than that induced by cevimeline in rats. Therefore, in the present study, sialogogue-induced intracellular Ca(2+) mobiliza...

Parotid fluid corticosteroids, substantially comprised of cortisol and cortisone, were previously demonstrated to rise to far greater levels 4 hr after administration of ACTH than they did in the third trimester of pregnancy, although the plasma total corticosteroid concentrations were similar in these two states. It was therefore suggested that only nonproteinbound corticosteroid gains access ...

Parotid gland and cerebellum metastasis in lung cancer are extremely rare; very few cases have been reported. Here we present a case of a 56-year-old Chinese female patient who presented with a swelling in the right parotid gland. We diagnosed metastatic squamous-cell carcinoma from advanced lung cancer. The patient received 1 cycle nimustine (100 mg/m2 IV Day 1) and nedaplatin (80 mg/m2 IV Day...

OBJECTIVES/HYPOTHESIS To examine how preoperative imaging characteristics correlate with sialendoscopic findings and operative outcomes in patients with obstructive parotid symptoms. STUDY DESIGN Retrospective review. METHODS We identified 112 consecutive patients who underwent 134 unilateral or bilateral parotid gland sialendoscopies between December 2005 and August 2013. We reviewed clini...

β-Adrenoceptor activation increases intracellular cAMP levels and consequently induces exocytotic amylase release in parotid acinar cells. Phosphodiesterase (PDE) catalyses the hydrolysis of cAMP, which terminates the downstream signaling of this second messenger. We investigated the involvement of PDE4, a cAMP-PDE, in β-adrenoceptor agonistinduced amylase release in mouse, rat and rabbit parot...

The intimate anatomical relationship of the facial nerve to the parotid parenchyma has a significant influence on the presenting signs and symptoms, diagnosis and treatment of parotid neoplasms. However, to our knowledge, hyperactivity of this nerve, presenting as facial spasm, has never been described as the presenting sign or symptom of a parotid malignancy. We report a case of carcinoma aris...

Synaptotagmin is a Ca2+ sensing protein, which triggers a fusion of synaptic vesicles in neuronal transmission. Little is known regarding the expression of Ca2+-dependent synaptotagmin isoforms and their contribution to the release of secretory vesicles in mouse and rat parotid acinar cells. We investigated a type of Ca2+-dependent synaptotagmin and Ca2+ signaling in both rat and mouse parotid ...

The authors investigated the association between cellular phone use and epithelial parotid gland malignancy. The subjects were 136 cases who were treated for this condition at the authors' hospital from January 1993 to March 2010, and 2051 controls who did not have salivary gland tumours and were admitted to the oral and maxillofacial surgery department during the same period. Logistic analysis...