Objective: To assess the effectiveness and accuracy of deep brain stimulation in Parkinsonian Disease (PD).
 Methods: This study was a descriptive prospective study, patients were treated at Neurospinal Cancer Care Institute Karachi, from February 1, 2016, to June 30, 2020. We had 21 cases parkinsonian disease. Inclusion criteria Idiopathic Parkinson’s disease, marked motor fluctuations ag...

objective(s) the aim of this study was to evaluate the effects of dexamethasone on striatal dopaminergic, glutamatergic and gamma amino butyric acid (gaba) ergic neurotransmission in normal and parkinsonian rats. materials and methods dexamethasone (0.15, 0.30, 0.60 and 0.8 mg/kg) was administered to normal or parkinsonian rats (i.p.) followed by the analysis of the striatal neurotransmitters c...

The recently identified C9orf72 gene accounts for a large proportion of amyotrophic lateral sclerosis and frontotemporal lobar degenerations. As several forms of these disorders are associated with parkinsonism, we hypothesized that some patients with Parkinson's disease or other forms of parkinsonism might carry pathogenic C9orf72 expansions. Therefore, we looked for C9orf72 repeat expansions ...

Gait difficulties--including freezing of gait--are frequent and disabling symptoms of advanced Parkinson's disease and other parkinsonian syndromes. They respond poorly to current medical and surgical treatments, making patient management very difficult. The underlying pathophysiology remains largely unknown. The late onset of levodopa resistance of Parkinson's disease gait abnormalities has be...

BACKGROUND Drug-induced parkinsonism is a well-known complication of several different drugs--the most common being neuroleptic-induced parkinsonism. However, very few autopsies have been reported in such cases. METHODS Patients assessed at Movement Disorders Clinic Saskatchewan are offered brain autopsy. Detailed clinical records are kept. RESULTS Brains were obtained from 7 drug-induced p...

OBJECTIVES To study different radiological signs and sequences including apparent diffusion coefficient (ADC) and gradient echo (GRE) to differentiate degenerative parkinsonian syndromes. BACKGROUND Multiple system atrophy (MSA), Parkinson's disease (PD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CbD) differ in the pattern of neurodegeneration and cellular damage. Me...

Prof. Seong-Hee Choi, PhD, Department of Audiology and Speech-Language Pathology and Research Institute of Biomimetic Sensory Control, College of Medical Sciences, Catholic University of Daegu, 5 Gumgokri, Hayangup, Kyungsansi, Kyungsanbookdo, Korea e-mail: [email protected] tel.: +82 53 850 3841 Background & Objectives: Lee Silverman Voice Treatment (LSVT) has been widely accepted to improve Pa...

Dyskinesia represents a debilitating complication of L-3,4-dihydroxyphenylalanine (L-dopa) therapy for Parkinson's disease. Such motor manifestations are attributed to pathological activity in the motor parts of basal ganglia. However, because consistent funneling of information takes place between the sensorimotor, limbic, and associative basal ganglia domains, we hypothesized that nonmotor do...

BACKGROUND SPECT is one of the most employed techniques in the diagnostic workup of idiopathic Parkinson's disease (IPD). Despite its widespread use, the exact diagnostic accuracy of this technique in parkinsonian syndromes remains controversial. METHODS In this study, we investigated the diagnostic accuracy of an initial (123)I-ioflupane (FP-CIT) and/or (123)I-iodobenzamide (IBZM) SPECT to d...

The application of radiomics for non-oncologic diseases is currently emerging. Despite its relative infancy state, the evidence highlights potential approaches to serve as neuroimaging biomarkers in field neurodegenerative brain. This systematic review presents last progress and nuclear imaging applied positron-emission tomography (PET) single-photon emission computed (SPECT) by focusing mainly...