Preliminary evidence suggests that daytime sleepiness may predate clinical diagnosis of Parkinson disease. The authors examined daytime napping and nighttime sleeping durations, reported in 1996–1997 by 220,934 US NIH-AARP Diet and Health Study participants, in relation to Parkinson disease diagnoses at 3 clinical stages: established (cases diagnosed before 1995, n 1⁄4 267), recent (1995–1999, ...

Parkinson disease is an age-related disorder of the central nervous system principally due to loss of dopamine-producing cells in the midbrain. Levodopa, in combination with carbidopa, is widely regarded as an effective treatment for the symptoms of Parkinson disease. A dose-response relationship is established for carbidopa-levodopa extended-release capsules (IPX066) in levodopa-naive Parkinso...

conclusions since the severity of the behavioral symptoms in the 6-ohda-induced model of parkinson disease reflects the degree of the lesion in substantia nigra (sn) dopaminergic neurons, it is suggested that using the combination had neuroprotective effects. the obtained data suggest a synergistic neuroprotective and antiparkinsonian effect for flu, glib and b com. at least, a part of this eff...

Objetivo: Analisar a tecnologia instrucional no contexto da qualidade de vida dos cuidadores idosos com Doença Parkinson. Método: o estudo é uma revisão integrativa literatura baseada na pergunta norteadora “qual importância acometidos pela Parkinson?”. Estas buscas iniciaram em outubro 2021 e foram até dezembro 2021, cujas bases consultadas foram: Medline, Scielo, Lilacs, Repositório Instituci...

A surface electrocardiogram showing type B Wolff-Parkinson-White syndrome pattern was part of the cardiac findings in a female of 24 with florid features of tuberous sclerosis. She had cardiomegaly but no intracardiac tumour was demonstrated. Wolff-Parkinson-White syndrome, though rare, has previously been described in association with tuberous sclerosis in children but not before in adults.

5 Interactions of stroke, nonsteroidal anti-inflammatory drugs, and APOE status in dementia risk 7 ␣-Synuclein gene duplications in sporadic Parkinson disease Jessie Theuns and Christine Van Broeckhoven ARTICLES 9 Joint effect of stroke and APOE 4 on dementia risk: The Canadian Study of Health and Aging 43 ␣-Synuclein gene duplication is present in sporadic Parkinson disease

A major és minor depresszió prevalenciája Parkinson-kórban szenvedôk között körülbelül 30-40%, ugyanakkor a depresszió ebben a betegcsoportban aluldiagnosztizált és alulkezelt kórkép. A depresszió diagnózisának és az adekvát kezelésének elmaradása nemcsak a depressziós tünetek perzisztálásához, de csökkent életminôséghez, az alapbetegség súlyosabb tüneti képéhez és kedvezôtlenebb prognózisához ...

BACKGROUND Neuronal degeneration and dopamine loss in the preclinical phase of Parkinson disease may produce subtle complaints before clinically recognizable symptoms emerge. OBJECTIVE To examine whether subjective complaints of stiffness, slowness, tremors, or postural imbalance in persons without clinical signs of parkinsonism are related to an increased risk of future Parkinson disease. ...

OBJECTIVE To assess the response to the rotigotine transdermal system (Neupro; Schwarz Pharma Ltd, Monheim, Germany), a nonergolinic dopamine agonist, in patients with early Parkinson disease. DESIGN Randomized, double-blind, multicenter, placebo-controlled study. SETTING Fifty sites in the United States and Canada. PATIENTS Two hundred seventy-seven patients with early Parkinson disease....