نتایج جستجو برای: parasitemia

تعداد نتایج: 2209  

2016
Gregory C Davenport James B Hittner Vincent Otieno Zachary Karim Harshini Mukundan Paul W Fenimore Nicolas W Hengartner Benjamin H McMahon Prakasha Kempaiah John M Ong'echa Douglas J Perkins

Bacteremia and malaria coinfection is a common and life-threatening condition in children residing in sub-Saharan Africa. We previously showed that coinfection with Gram negative (G[-]) enteric Bacilli and Plasmodium falciparum (Pf[+]) was associated with reduced high-density parasitemia (HDP, >10,000 parasites/μL), enhanced respiratory distress, and severe anemia. Since inflammatory mediators ...

Journal: :Eukaryotic cell 2010
Brian T Emmer Melvin D Daniels Joann M Taylor Conrad L Epting David M Engman

African trypanosomes express a family of dually acylated, EF-hand calcium-binding proteins called the calflagins. These proteins associate with lipid raft microdomains in the flagellar membrane, where they putatively function as calcium signaling proteins. Here we show that these proteins bind calcium with high affinity and that their expression is regulated during the life cycle stage of the p...

Journal: :International journal of laboratory hematology 2014
C Opoku-Okrah M Gordge E Kweku Nakua T Abgenyega M Parry C Robertson C L Smith

INTRODUCTION Several factors influence the severity of Plasmodium falciparum; here, we investigate the impact of alpha+-thalassaemia genotype on P. falciparum parasitemia and prevalence of severe anaemia amongst microcytic children from Kumasi, Ghana. METHODS Seven hundred and thirty-two children (≤10 years) with P. falciparum were categorised into normocytic and microcytic (mean cell volume ...

Journal: :The American journal of tropical medicine and hygiene 2005
D Gray Heppner Douglas S Walsh Nichapat Uthaimongkol Douglas B Tang Somchit Tulyayon Barnyen Permpanich Theera Wimonwattrawatee Niphon Chuanak Anintita Laoboonchai Prasit Sookto Thomas G Brewer Philip McDaniel Chirapa Eamsila Kosol Yongvanitchit Kathleen Uhl Dennis E Kyle Lisa W Keep Robert E Miller Chansuda Wongsrichanalai

We assessed the prophylactic efficacy of azithromycin (250 mg/day) against malaria in 276 adults in western Thailand in a randomized, double-blind, placebo-controlled trial. After antimalarial suppressive treatment, volunteers were randomized in a 2:1 ratio to either the azithromycin or placebo, respectively. Study medication was given for an average of 74 days. The azithromycin group (n = 179)...

Journal: :The Analyst 2014
K M Davis L E Gibson F R Haselton D W Wright

Lateral flow immunochromatographic rapid diagnostic tests (RDTs) are the primary form of medical diagnostic used for malaria in underdeveloped nations. Unfortunately, many of these tests do not detect asymptomatic malaria carriers. In order for eradication of the disease to be achieved, this problem must be solved. In this study, we demonstrate enhancement in the performance of six RDT brands w...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1996
S Merino J Potti J Moreno

The relationships between parental effort, offspring growth, and offspring blood parasitemias are poorly known. We examined the effect of parental effort on offspring size and prevalence of trypanosomes in peripheral blood of nestling Pied Flycatchers Ficedula hypoleuca aged 13 days. Trypanosome infections were likely to be shared by siblings, indicating the role of a common environment and/or ...

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012
Isaac I Bogoch Benjamin T Davis David C Hooper

To the Editor—A 57-year-old woman from Cape Cod presented to our facility with fever and a syncopal episode. She reported 1 week of fatigue before her evaluation. On examination, she was febrile (38.6 C) but otherwise appeared well, with a positive Castell’s sign and palpable spleen tip. Her medical history was significant for Crohn’s disease treated with infliximab, with the most recent dose a...

Journal: :Science 2003
Travis Harrison Benjamin U Samuel Thomas Akompong Heidi Hamm Narla Mohandas Jon W Lomasney Kasturi Haldar

Erythrocytic mechanisms involved in malarial infection are poorly understood. We have found that signaling via the erythrocyte beta2-adrenergic receptor and heterotrimeric guanine nucleotide-binding protein (Galphas) regulated the entry of the human malaria parasite Plasmodium falciparum. Agonists that stimulate cyclic adenosine 3',5'-monophosphate production led to an increase in malarial infe...

Journal: :Infection and immunity 1990
M M Stevenson M F Tam M Belosevic P H van der Meide J E Podoba

The role of gamma interferon (IFN-gamma), a pluripotent lymphokine capable of activating macrophages, in acquired immunity to blood-stage malaria was investigated. C57BL-derived, lipopolysaccharide-resistant C57BL/10ScN mice, which were found to be resistant to intraperitoneal (i.p.) infection with 10(6) Plasmodium chabaudi AS parasitized erythrocytes, were treated with monoclonal anti-IFN-gamm...

Journal: :Clinical Phytoscience 2021

Abstract Background Malaria has continued to be a threat man and his wellbeing, especially Africans Asians. New antimalarial drugs are urgently needed mitigate malaria treatment failure due resistant Plasmodium species . Medicinal plants used by indigenous Nigerians for treating fever such as Sida acuta Burm.f. (Malvaceae) could promising source of lead compounds developing new generations drug...

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