The balance between the products of L-arginine metabolism in macrophages regulates the outcome of Leishmania major infection. L-arginine can be oxidized by host inducible NO synthase to produce NO, which contributes to parasite killing. In contrast, L-arginine hydrolysis by host arginase blocks NO generation and provides polyamines, which can support parasite proliferation. Additionally, Leishm...

Helminth parasites remain one of the most common causes of infections worldwide, yet little is still known about the immune signaling pathways that control their expulsion. C57BL/6 mice are chronically susceptible to infection with the gastrointestinal helminth parasite Heligmosomoides polygyrus. In this article, we report that C57BL/6 mice lacking the adapter protein MyD88, which mediates sign...

PURPOSE The purpose was to determine the number of semantic neighbors, namely, semantic set size, for 88 nonobjects (J. F. Kroll & M. C. Potter, 1984) and determine how semantic set size related to other measures and age. METHOD Data were collected from 82 adults and 92 preschool children in a discrete association task. The nonobjects were presented via computer, and participants reported the...

In the present article we observe the significations and the dimensions of interaction between instruments and performers in musical performance. This will lead us, firstly, to consider interaction as a phenomenon non-exclusively correlated with the use of numeric technologies. Then, still within the realm of interaction, we describe some of the transmutations introduced by digital music instru...

Chagas disease is caused by the protozoan Trypanosoma cruzi. The parasite reaches the secondary lymphoid organs, the heart, skeletal muscles, neurons in the intestine and esophagus among other tissues. The disease is characterized by mega syndromes, which may affect the esophagus, the colon and the heart, in about 30% of infected people. The clinical manifestations associated with T. cruzi infe...

Study of proteins located at the host-parasite interface in schistosomes might provide clues about the mechanisms utilized by the parasite to escape the host immune system attack. Micro-exon gene (MEG) protein products and venom allergen-like (VAL) proteins have been shown to be present in schistosome secretions or associated with glands, which led to the hypothesis that they are important comp...

We have functionally analyzed the orthologous SRPN6 genes from Anopheles stephensi and Anopheles gambiae using phylogenetic, molecular, reverse genetic, and cell biological tools. The results strongly implicate SRPN6 in the innate immune response against Plasmodium. This gene belongs to a mosquito-specific gene cluster including three additional Anopheles serpins. SRPN6 expression is induced by...

background: the study evaluated qualitative pcr, primers 121-122 as a tool to follow up evolution parasite load of trypanosoma cruzi . methods: the study was conducted at the state university of maringa, in 2015. step 1, dilutions 1/10 were performed from t. cruzi -y strain to obtain preparations of 50,000-0.05 parasites/ml from which dna were extracted, quantified, and amplified. step 2, the e...

some parasites can be transferred from fish to human via eating of contaminated meat and make serious problems in consumers. in the present study zoonotic parasites of abdominal cavity in pike-perch, sander lucioperca, in south eastern part of the caspian sea have been surveyed. in this regard, 30 fish were caught by purse seine net and abdominal cavity, digestive tract and other organs (kidney...