نتایج جستجو برای: paraoxonase

تعداد نتایج: 2123  

Journal: :Japanese Journal of Thrombosis and Hemostasis 2012

Journal: :European Journal of Human Genetics 2004

Journal: :Bratislava Medical Journal 2013

Journal: :Chemico-Biological Interactions 2016

Journal: :Environmental Health Perspectives 2007

2008
John E. Landers Lijia Shi Ting-Jan Cho Jonathan D. Glass Christopher E. Shaw P. Nigel Leigh Frank Diekstra Meraida Polak Ildefonso Rodriguez-Leyva Stephan Niemann Bryan J. Traynor Diane Mckenna-Yasek Peter C. Sapp Ammar Al-Chalabi Anne-Marie A. Wills Robert H. Brown

Amyotrophic lateral sclerosis (ALS) is a progressive, neurodegenerative disorder of upper and lower motor neurons. Genetic variants in the paraoxonase gene cluster have been associated with susceptibility to sporadic ALS. Because these studies have yielded conflicting results, we have further investigated this association in a larger data set. Twenty SNPs spanning the paraoxonase gene cluster w...

Journal: :The Journal of biological chemistry 2000
H Jakubowski

Homocysteine thiolactone is formed in all cell types studied thus far as a result of editing reactions of some aminoacyl-tRNA synthetases. Because inadvertent reactions of thiolactone with proteins are potentially harmful, the ability to detoxify homocysteine thiolactone is essential for biological integrity. This work shows that a single specific enzyme, present in mammalian but not in avian s...

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