The pyruvate dehydrogenase enzyme complex (PDC) is rate limiting for glucose oxidation in the heart. Inhibition of PDC by end-product feedback and phosphorylation by pyruvate dehydrogenase kinase (PDK) operate in concert to inhibit PDC activity. Because the transcriptional regulator peroxisome proliferator-activated receptor (PPAR)-alpha increases PDK expression in some tissues, we examined wha...

UNLABELLED Endocrine orbitopathy (EO) is the most common extrathyroidal manifestation of Graves disease (GD) but the involvement of the underlying immunological dysregulations remains largely unknown. The major source for IFNa-production, plasmacytoid dendritic cells (PDC) are fundamentally involved in the integration of TH1 and TH2 immune responses but also implicated in the pathogenesis of au...

PURPOSE The purpose of the study was to empirically test items of a new measure designed to assess person-directed care (PDC) practices in long-term care. DESIGN AND METHODS After reviewing the literature, we identified five areas related to PDC: personhood, comfort care, autonomy, knowing the person, and support for relationships. We also identified an additional component of environmental s...

PURPOSE This article provides a detailed description of a telephone-based care coordination intervention, Partners in Dementia Care (PDC), for veterans with dementia and their family caregivers. Essential features of PDC included (a) formal partnerships between Veterans Affairs (VA) medical centers and Alzheimer's Association Chapters; (b) a multidimensional assessment and treatment approach, (...

Type I IFNs display multiple biological effects. They have a strong antiviral action, not only directly but also indirectly through activation of the immune system. They may also have actions that are deleterious for the host. The cells that produce type I IFN are mostly plasmacytoid dendritic cells (pDC), but this depends on the viral stimulus. The migration and distribution of pDC into lympho...

This paper considers the identification and fuzzy controller design for nonlinear uncertain systems in presence of unknown input time-delay. Firstly, a time-delay Takagi-Sugeno-Kang (TSK) type fuzzy neural system (TDFN) is proposed to identify a class of nonlinear input time-delay systems. The input-output signals of nonlinear systems are used to identify the system dynamics and unknown time-de...

The asymmetric unit of the title compound, {[Eu(C(7)H(3)NO(4))Cl(CH(3)OH)(2)]·CH(3)OH}(n), contains one Eu(III) ion, one pyridine 2,3-dicarboxylate dianion (PDC), two CH(3)OH mol-ecules coordinating to the metal atom, one coordinating chloride and one lattice occluded CH(3)OH mol-ecule. In the crystal, each PDC anion coordinates to three adjacent Eu(III) ions by the pyridine N and O atoms of th...

High-precision radiometric calibration and synchronization compensation must be provided for distributed radar system due to separate transmitters and receivers. This paper proposes a transponder-aided joint radiometric calibration, motion compensation and synchronization for distributed radar remote sensing. As the transponder signal can be separated from the normal radar returns, it is used t...