Acute ruminal acidosis is a metabolic status defined by decreased blood pH and bicarbonate, caused by overproduction of ruminal D-lactate. It will appear when animals ingest excessive amount of nonstructural carbohydrates with low neutral detergent fiber. Animals will show ruminal hypotony/atony with hydrorumen and a typical parakeratosis-rumenitis liver abscess complex, associated with a pleth...

Fig 1. Papular acantholytic dyskeratosis. Red-pink verrucous papules in a linear distribution. CASE REPORT A 78-year-old man was hospitalized for resection of a craniopharyngioma. His postoperative course was complicated by infections and a 4-month-long hospitalization. The dermatology department was consulted because of a new inguinal rash. The patient noted a 7-day history of a nonpruritic, n...

A 44-year-old female suffered from chronic recurrent papules, vesicles and pustules on bilateral soles and heels for more than 1 year. It was associated with painful and itchy sensation. She had been treated as having pompholyx at a local hospital. The lesions improved partially but soon flared up after discontinuing the treatment. This time, she suffered from erythematous papuloplaques on bila...

CXCR4 is expressed by basal keratinocytes (KCs), but little is known about its function in inflamed skin. We crossed K14-Cre and CXCR4(flox/flox (f/f)) transgenic mice, resulting in mice with specific loss of the CXCR4 gene in K14-expressing cells (K14-CXCR4KO), including basal KCs. K14-CXCR4KO pups had no obvious skin defects. We compared K14-CXCR4KO and CXCR4(f/f) control mice in an IL-23-med...

INTRODUCTION Verruciform xanthoma is a rare, benign lesion characterized by hyperkeratosis and aggregates of foam cell macrophages. Here, we describe a case of verruciform xanthoma on the scrotum, in which the immunohistochemical localization of monocyte chemoattractant protein-1, a chemokine of the C-C or beta family that has been shown to induce the recruitment of monocytes for injured tissue...

Pendahuluan : Giant kondiloma akuminata sering dikaitkan dengan HPV tipe 6 dan 11, namun memiliki perbedaan anal pada umumnya, seperti papilomatosis yang berbatas tegas, akantosis, rete ridges memanjang, meningkatnya aktivitas mitosis. Kasus: Pria, umur 33 tahun, keluhan muncul benjolan menyerupai kembang kol di sekitar lubang dubur terasa gatal sejak 1 tahun lalu. Pemeriksaan status venereolog...

The ABCA12 gene encodes an ATP-binding cassette transporter vital to skin barrier function. In keratinocytes, transports ceramides into the lumen of lamellar bodies as part widely conserved water system. Alterations in are associated with autosomal recessive congenital ichthyoses: harlequin ichthyosis, non-bullous ichthyosiform erythroderma, and ichthyosis. We report a 4-month-old female who pr...

Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 (AMP-IBP5) is expressed in keratinocytes and displays both antimicrobial immunomodulatory properties. In contrast to many peptides (AMPs), factor-binging 5, the parent of AMP-IBP5, downregulated psoriasis, an inflammatory skin disease characterized by epidermal hyperplasia, erythematous plaques, abnormal differentia...

N6-methyladenosine (m6A) is the most prevalent internal modification of mRNA in eukaryotes, and it involved various biological pathological processes. Psoriasis atopic dermatitis (AD) are considered as common chronic inflammatory skin diseases, both them feature epidermal acanthosis, hyperkeratosis, parakeratosis, infiltration immune cells well dermal changes. To reveal effect m6A keratinocytes...