The toxic effects of paracetamol in overdose quantities are well recognised but the occurrence of anaphylactoid reactions to paracetamol is infrequently identified by consumers and health care professionals. Nevertheless adverse reactions to this drug, even in therapeutic doses, can have fatal or near fatal consequences. A case of an anaphylactoid reaction to paracetamol is described.

Effect of paracetamol on renal clearance and urinary excretion of isoniazid was investigated in eight healthy adult female goats in two phases. In the first phase, each goat was administered isoniazid orally as a single dose at the rate of 10 mg/kg body weight. A washout period of 7 days was given before the second phase in which the same dose of isoniazid was administered along with paracetamo...

BACKGROUND AND PURPOSE The presumed safety of paracetamol in high-cardiovascular risk patients has been questioned. We determined whether paracetamol or ibuprofen use is associated with major cardiovascular events (MACE) or major bleeding in 19 120 patients with recent ischemic stroke or transient ischemic attack of mainly atherothrombotic origin included in the Prevention of cerebrovascular an...

This is a three-year retrospective review of 96 cases of paracetamol ingestions seen by KK Children's Emergency Department. Paracetamol is the commonest substance (23%) involved in childhood poisonings. More than 60% occurred in children aged one to three years old with an equal gender distribution. Eighty-six percent were accidental ingestions and the intentional ones had a significant female ...

Iatrogenic Paracetamol toxicity is a potentially life-threatening yet avoidable cause of acute liver failure. Unfortunately, several cases have recently been reported nationally (1,2). The impetus behind our project was a recent case of iatrogenic Paracetamol induced hepatotoxicity within our trust, a London-based District General Hospital. According to the British National Formulary, for adult...

Studies were performed on 670 male mice of Swiss strain. Cernilton (mixture of preparation Cernitin T-60-100 mg/kg and Cernitin GBX--20 mg/kg emulsified by using Imwitor 370) was intraperitoneally administered in a volume of 30 ml/kg of body mass. LD50 of paracetamol was fixed after intraperitoneal administration. Certimilton was given 1 h before or 1 h after paracetamol in a dose LD100 and LD5...

OBJECTIVE To study the effect of paracetamol (acetaminophen) on maternal and fetal temperatures in labour. STUDY DESIGN From a cohort of 185 women with continuous maternal axillary and fetal scalp temperature recordings in labour, 18 women treated with 1000mg paracetamol orally for pyrexia and 36 untreated controls matched for parity, cervical dilatation, and epidural analgesia were selected....

BACKGROUND Paracetamol is the first choice for antipyretic or analgesic treatment throughout pregnancy. Products with Paracetamol are readily available over the counter and therefore easily accessible for self-medication. Epidemiological data on Paracetamol intake pattern during pregnancy and its potential immunological effects are sparse. We aimed to analyze a possible association between Para...

We previously showed that the largely used analgesic paracetamol has several adverse effects, impacts the central nervous system, and leads to habituation as well as dependence. An extract of the rhizome of Curcuma longa is known for having analgesic properties, and may thus be used instead of paracetamol if it has no or very few adverse effects. Examining this food complement exactly as we exa...

OBJECTIVE To compare the efficacy and safety of oral paracetamol and oral ibuprofen for the pharmacological closure of patent ductus arteriosus (PDA) in preterm infants. STUDY DESIGN This prospective, randomized, controlled study enrolled 90 preterm infants with gestational age ≤ 30 weeks, birthweight ≤ 1250 g, and postnatal age 48 to 96 hours who had echocardiographically confirmed significa...