We developed mice deficient in protease-activated receptor-2 (PAR-2) or PAR-1 to explore the pathophysiological functions of these receptors. In this report, we evaluated mean arterial pressure and heart rate (HR) changes in response to PAR-1 or PAR-2 activation in anesthetized wild-type (WT), PAR-1-deficient (PAR-1(-/-)), and PAR-2-deficient (PAR-2(-/-)) mice. In WT mice, TFLLRNPNDK, a PAR-1 s...

The purpose of this study was to determine whether thermoplastic retainers need to be worn full-time for a limited period or whether part-time wear from the outset is adequate to maintain tooth position, arch form, and occlusion. This study was a randomized clinical trail, conducted in a district general hospital. Sixty-two participants were enrolled in the study. Group 1, full-time wear, consi...

Processing graphical data, either for its editing or the synthesis of new content, demands agood balance between the different sources of information one may exploit. Unlike "proce-dural" techniques, synthesis by example stands out thanks to its extreme ease-of-use : indeed,tasks such as identification, analysis and reproduction of the distinguishing features of the user-provide...

ion de prédicats L’abstraction de prédicats peut être utilisée pour améliorer l’analyse d’accessibilité. Elle consiste à analyser la valeur de vérité d’un ensemble de prédicats plutôt que de calculer des ensembles d’état continus [6, 5]. Des techniques de raffinement guidées par les contre-exemples [30] sont une autre application importante de cette approche. Ces techniques ont été utilisées da...

[1] Time-series observations of optical fields in the euphotic layer and particle fluxes at 150 m were made in the western North Pacific for half year of 2005. The ratio of surface photosynthetically available radiation (surface PAR) to in situ quantum irradiance at ca. 40 m (in situ QI), as an index of turbidity, began to increase in the middle of April, peaking between the end of June and the...

18 Background and aims: Most optical devices for indirect measurement of leaf area 19 index (LAI) from canopy-transmitted light are tailored for homogeneous canopies, thus 20 limiting their application to discontinuous canopies such as vertically trained vineyards. 21 This study evaluates the influence of sun position on the reliability of LAI estimates 22 provided by a ceptometer and proposes ...

Extravascular activation of the coagulation cascade in the lung is commonly observed in pulmonary fibrosis. Coagulation proteases may exert profibrotic cellular effects via protease-activated receptors (PARs)-1 and -2. Here, we investigated the potential role of two other members of the PAR family, namely PAR-3 and PAR-4, in the pathobiology of lung fibrosis. Elevated expression of PAR-3, but n...

The coagulation and fibrinolytic systems contribute to malignancy by increasing angiogenesis, tumor growth, tumor invasion, and tumor metastasis. Oncogenic transformation increases the expression of tissue factor (TF) that results in local generation of coagulation proteases and activation of protease-activated receptor (PAR)-1 and PAR-2. We compared the PAR-dependent expression of urokinase pl...

radio frequency identification (rfid) is used to identify the characteristics of an object wirelessly using radio waves. the purpose of this technology in this study is mainly focused on healthcare for inventory management and theft control replacing the manual logs. the storage and tracking of high-cost inventory items is developed. automatic reordering and billing interfaces are designed for ...