Warty dyskeratoma (WD) is a rare epidermal tumor that frequently arises as a papule or nodule on the head or neck of middle-aged or older persons. Histologically, it shows a cup-shaped keratin-filled invagination of an acanthotic epidermis, suprabasilar clefting with villi projecting into the clefts and acantholytic dyskeratotic cells are also present. The changes almost always involve a single...

IMPORTANCE Vismodegib is a Hedgehog signaling pathway inhibitor recently approved by the US Food and Drug Administration for advanced basal cell carcinoma. We present 2 cases of clinically significant squamous cell carcinoma within the tumor bed of locally advanced basal cell carcinoma found during vismodegib treatment. OBSERVATIONS The first case is that of a patient with locally advanced ba...

INTRODUCTION Trikatu is composed of dried fruits of Piper nigrum L and Piper retrofractum Vahl, and dried rhizomes of Zingiber officinale R. Although this preparation has been used to relieve pruritis, pain, and inflammation for a long time, there is no clinical evidence to confirm its efficacy and safety. Therefore, we performed a double-blind, within person-randomized controlled study of 30 h...

A 33-year-old woman with no underlying systemic disease visited our hospital with a tender, hyperpigmented skin tumor over the right lateral chest wall for 6 months. Initially, the lesion was a small hemorrhagic cutaneous papule. Perifocal hyperpigmentation developed progressively and the lesion gradually enlarged to 2 cm at its greatest diameter. On physical examination, a painful illdefined m...

Pyogenic granuloma is a hemorrhagic nodule that happens utmost often on the gingiva (although it can occur any surface) and has robust penchant to persist after simple excision if connected irritant not removed. Clinically these lesions usually present as single or sessile papule with smooth lobulated surface. These may be seen in size from few millimeters several centimeters. Here, we report c...

Epidermal cyst (EC) of the skin is a very common condition. Squamous cell carcinoma (SCC) very infrequently arises from EC. A 76-year-old Japanese woman was admitted to our hospital because of multiple papules in the nose and nasal cavity. The clinical diagnosis was sebaceous hyperplasia. An excisional biopsy was obtained from one papule. Histologically, the papule showed an EC. The EC communic...

Case report. A 24-year-old male patient reported he had undergone removal of a brownish lesion recently appeared on a congenital lesion of the scalp and noticed its recurrence one month after the removal. The dermatological examination showed a just raised, grossly rectangular, 2 x 1.5 cm yellow plaque, with grainy surface and irregular borders; in the middle of the plaque there was no hair but...

INTRODUCTION Cow's milk protein allergy is the most common allergy in pediatrics. Immunoglobulin E (IgE)-mediated cow's milk allergy poses a higher risk for life and a worse prognosis. OBJETIVES To describe the course of IgE-mediated cow's milk protein allergy and risk factors associated with disease persistence. PATIENTS AND METHODS This was a descriptive, retrospective study conducted in ...