BACKGROUND Follicular variant of papillary thyroid cancer (FV-PTC) is the second most common subtype of papillary thyroid cancer (PTC) after classic PTC. FV-PTC is characterized by nuclear features consistent with classic PTC but has a follicular architecture that lacks classic papillary morphology. Thyroid cancer rarely metastasizes to the kidney. Only 6 cases of FV-PTC metastasizing to the ki...

HYPOTHESIS Discontinuous nodal metastasis, or skip metastasis, in thyroid cancer may display clinicopathologic features different from those seen in continuous nodal metastasis and thus may have a different prognosis. DESIGN Retrospective analysis. SETTING Tertiary referral center at a university hospital. PATIENTS Two hundred fifteen consecutive patients who underwent systematic central ...

Some medical defi nitions remain the same for many years, others change due to the progress in the diagnostic tools, which are able to distinguish markers and symptoms until then undetectable. Occult thyroid carcinoma is a general term indicating clinically different situations, whereas the incidentally detected papillary thyroid microcarcinoma is the most important from the clinical point of v...

Thyroid cancer accounts for approximately 1% of total cancer cases in developed countries. The aim of this study has been to analyze the histopathological variants of thyroid tumours with regard to gender and age. Despite their relative rarity in our material, they exhibit a wide range of morphological patterns and biological behaviour. During the period from 2001-2007, 138 biopsy cases of thyr...

Interactions between cytokines and others soluble factors (hormones, antibodies...) can play an important role in the development of thyroid pathogenesis. The purpose of the present study was to examine the possible correlation between serum cytokine concentrations, thyroid hormones (FT4 and TSH) and auto-antibodies (Tg and TPO), and their usefulness in discriminating between different thyroid ...

BACKGROUND Many studies have reported an increased risk of developing a second primary malignancy (SPM) of the breast in women treated for thyroid cancer. In this study, we investigated several potential risk factors for this association. The aim of this retrospective cohort study was to identify a subgroup of women surgically treated for papillary thyroid cancer that may benefit from more care...

Nobody wants to get cancer, but if you have to, thyroid cancer is a good one to get because of its excellent prognosis. Still, there is plenty of room for improvement in the current approaches to the diagnosis and therapy of this disease. Thyroid cancer is the most common endocrine malignancy. The American Cancer Society estimates 37 000 new cases of thyroid cancer were diagnosed in the US in 2...

Background The incidence of thyroid cancer—the most common endocrine cancer, mainly composed of papillary thyroid cancer (PTC; ~80%)—has increased worldwide over the past several decades. Known risk factors for thyroid cancer include a history of head and neck radiation, iodine deficiency or excess, and other thyroid disease. Although most cases of PTC are sporadic, a small proportion may be ge...

The transformation of endodermal-derived thyroid follicular cells or neural crest– derived thyroid C cells leads to distinct types of cancer (Fig. 1). Follicular cells give rise to two main forms of differentiated thyroid cancer: papillary thyroid carcinoma and follicular thyroid carcinoma. Poorly differentiated and anaplastic thyroid carcinomas are comparatively rare tumors that also arise fro...

Background and Objective: Thyroid cancer is the most frequent endocrine malignancy in the world and papillary carcinoma is the most frequent thyroid carcinoma. Different markers used for determination of prognosis and VEGFR is one of them. The aim of present study was to determine the expression of Vascular Endothelial Growth Factor Receptor (VEGFR) as a prognostic marker in papillary carcinoma...