BACKGROUND We studied the imaginary coherence (IC) of gamma frequency oscillations between brain regions of male schizophrenia patients during an auditory oddball task using magnetoencephalography (MEG) and electroencephalography (EEG). METHODS Subjects were 10 right-handed male schizophrenia patients, evaluated by the positive and negative symptom scale (PANSS), and 10 healthy controls. Func...

BACKGROUND Psychosocial dysfunction is one of schizophrenia's core features, often leading to a deprecation of independent living and significant failure to maintain a competent quality of life. Cognitive and occupational performance as well as psychosocial functioning is moreover recognized as determinants of treatment response. Therefore, the elaboration of measures regarding social performan...

Treatment resistance to clozapine often leads to antipsychotic combinations. Well-designed trials evaluated the add-on of several atypical antipsychotics, but the augmentation with paliperidone, the active metabolite of risperidone, has never been evaluated. Treatment of four cases resulted in a decrease of the PANSS-positive subscale, the mean initial clozapine dose could be lowered, mean prol...

BACKGROUND Despite the wide use of the Excited Component of the Positive and Negative Syndrome Scale (PANSS-EC) in a clinical setting to assess agitated patients, a validation study to evaluate its psychometric properties was missing. METHODS Data from the observational NATURA study were used. This research describes trends in the use of treatments in patients with acute psychotic episodes an...

OBJECTIVE Adenosine has been reported to interact with dopamine and glutamate of which are currently central pathophysiology of schizophrenia. Further, there have been emerging reports that patients with bipolar disorder (BD) have pathophysiological changes of the purinergic system. Thus, we performed a systematic review and meta-analysis of adenosine modulators in these disorders. METHOD We ...

BACKGROUND Patients with schizophrenia suffer high rates of metabolic derangements on some antipsychotic medications that predispose them to cardiovascular diseases. Keeping this fact in mind, we planned this open-label study to see the effect on various metabolic parameters after switching stable schizophrenia subjects, who had developed metabolic syndrome on olanzapine, to aripiprazole. MET...

objective: the current study was performed to evaluate the cognitive improvements of the chronic schizophrenic patients treated with risperidone in comparison with those treated with haloperidol according to wisconsin card sorting test (wcst). methods: in a double blind clinical trial, 65 patients with a diagnosis of chronic schizophrenia were randomly allocated into two groups. they received a...

BACKGROUND Effective management strategies for the negative symptoms of schizophrenia remain an unmet need, and data on the use of antipsychotics in this population are scarce, particularly in Chinese patients. Therefore, we investigated amisulpride for the treatment of Chinese patients with predominantly negative symptoms of schizophrenia. METHODS This post hoc subanalysis of the prospective...

Patients with prominent negative symptoms consistently perform worse than other clinical groups on Theory of Mind (ToM) tasks. However, the nature of this relationship has not been closely examined. In this study, we investigated the relationship between ToM and the Scale for the Assessment of Negative Symptoms (SANS) components. We replicated our findings in two independent samples and at two ...

s | 45 Abstract Objective: The present study aimed to evaluate the efficacy and tolerability of blonanserin compared with other antipsychotics in the management of patients with schizophrenia. Methods: A systematic review and meta-analysis of randomized controlled trials comparing blonanserin head-to-head with other antipsychotics in schizophrenia were conducted. Embase, PubMed, the Cochrane Li...