Pancreatic cancer is one of the most deadly cancers with a poor prognosis. Though studies have implicated the roles of microRNAs in pancreatic cancer progression, little is known about the role of miR-613 in pancreatic cancer. In the present study, the expression of miR-613 was down-regulated in pancreatic cancer tissues and cancer cell lines. Down-regulation of miR-613 was positively correlate...

Pancreatic cancer is strongly associated with diabetes mellitus. About 80% of the patients with pancreatic ductal adenocarcinoma have glycometabolic alterations. On the contrary, patients with new-onset diabetes mellitus within 1-3 years have a significant increased risk of pancreatic neoplasm up to 5-8 folds. Long-standing diabetes increases the risk for pancreatic cancer, while pancreatic can...

Due to its aggressiveness and unusual resistance to conventional therapies, pancreatic cancer is a highly lethal gastrointestinal malignancy with poor prognosis. According to the cancer stem cell hypothesis, there exists a fraction of cancer cells, that is, cancer stem cells, responsible for tumor maintenance and therapeutic failure. Herein we investigated the involvement of proto-oncogene Pim-...

Pancreatic cancer is an aggressive disease and bears a dismal prognosis. Data on gender differences in this tumor entity are scare. In single center, real-world retrospective analysis of our registry for pancreatic cancer, we investigated compared the survival data inflammatory parameters male female patients. total, included 42 63 patients with metastatic cancer. Liver metastasis was comparabl...

Pancreatic cancer remains a disease that is very difficult to treat. S100 proteins are small calcium binding with diverse intra- and extracellular functions modulate different aspects of tumorigenesis, including tumor growth metastasis. High mobility group box 1 (HMGB1) protein multifaceted also actively influences the development progression tumors. In this study, we investigate possible corre...

Several dietary and medicinal herbs have been shown to be effective in the treatment prevention of cancer. Although Piper nigrum has anti-cancer activities against various cancer cells, its anti-pancreatic properties not reported. In present study, P. extract (PNE) inhibited proliferation PANC-1 human pancreatic cells. Flow cytometry showed G0/G1 arrest caused by PNE addition, Western blot anal...

BACKGROUND Telomeres, the ends of chromosomes, are critical for maintaining genomic stability and grow shorter with age. Shortened telomeres in pancreatic tissue play a key role in the pathogenesis of pancreatic cancer, and shorter telomeres in peripheral blood leukocytes (PBL) have been associated with increased risk for several cancer types. We hypothesized that shorter blood telomeres are as...

Press conference in Washington, DC to discuss pancreatic cancer federal funding http://www.pancan.org/section_about/news_press_center/2011_press_releases/02_16_11_pr.php On February 16, 2011, Pancreatic Cancer Action Network President and CEO Julie Fleshman, spokesperson Lisa Niemi Swayze, Senator Whitehouse (D-RI), and Representatives Eshoo (D-CA) and Lance (R-NJ) presented a press conference ...

The signal molecules that regulate pancreatic cancer growth are still poorly understood. We have previously reported that 5-lipoxygenase not expressed in normal pancreatic ductal cells, but was markedly upregulated and involved cell proliferation and survival in human pancreatic cancer. Pancreatic cancer cells produce a large amount of growth factors, which are important for maintaining pancrea...

PURPOSE Methylation of CpG islands contributes to gene silencing during cancer development, and although some methylation alterations are promising diagnostic markers of cancer, some CpG islands are also methylated in normal tissues. We have previously observed that some normally unmethylated CpG islands that undergo methylation in pancreatic cancers are normally methylated in the adjacent duod...