Pregnancy-associated malaria (PAM) is an important cause of maternal and neonatal suffering. It is caused by Plasmodium falciparum capable of inhabiting the placenta through expression of particular variant surface antigens (VSA) with affinity for proteoglycans such as chondroitin sulfate A. Protective immunity to PAM develops following exposure to parasites inhabiting the placenta, and primigr...

PAM (Protein Associated with Myc) is an almost ubiquitously expressed protein that is one of the most potent inhibitors of adenylyl cyclase activity known so far. Here we show that PAM is localized at the endoplasmic reticulum in HeLa cells and that upon serum treatment PAM is recruited to the plasma membrane, causing an inhibition of adenylyl cyclase activity. We purified the serum factor that...

Slow infiltration rates constrain effective and economical irrigation in some sandy loam soils in California. Polyacrylamide (PAM) has increased soil infiltration in some areas, especially in soils high in clay or silt. Field trials near Fresno, CA, with PAM failed to show improved infiltration. Laboratory experiments were conducted to investigate PAM effect on infiltration of various quality w...

ANP (atrial natriuretic peptide) is widely recognized as an important vasorelaxant, diuretic, and cardioprotective hormone. Little is known, however, about how ANP-secretory vesicles form within the atrial myocytes. Secretory vesicles were visualized by fluorescence microscope imaging in live rat atrial myocytes expressing proANP-enhanced green fluorescent protein (EGFP), or N-terminal-mutated ...

Amidated neuropeptides play essential roles throughout the nervous and endocrine systems. Mice lacking peptidylglycine α-amidating monooxygenase (PAM), the only enzyme capable of producing amidated peptides, are not viable. In the amidation reaction, the reactant (glycine-extended peptide) is converted into a reaction intermediate (hydroxyglycine-extended peptide) by the copper-dependent peptid...

During the anaerobic digestion of dewatered sludge, polyacrylamide (PAM), a chemical conditioner, can usually be consumed as a carbon and nitrogen source along with other organic matter (e.g., proteins and carbohydrates in the sludge). However, a significant accumulation of acrylamide monomers (AMs) was observed during the PAM biodegradation process. To improve the anaerobic hydrolysis of PAM, ...

background and objectives: in many studies, chronic diseases are associated with incidence of driving accident. the main objective of the present study is investigation the effect of physical and mental disorders status of bus drivers on the occurrence of crashes. materials and methods: this research is a cross-sectional and descriptive-analytical study that was performed on 665 bus drivers' pu...

background and objectives: in many studies, chronic diseases are associated with incidence of driving accident. the main objective of the present study is investigation the effect of physical and mental disorders status of bus drivers on the occurrence of crashes. materials and methods: this research is a cross-sectional and descriptive-analytical study that was performed on 665 bus drivers' pu...

Stock price crash risk is a phenomenon in which stock prices are subject to severe negative and sudden adjustments. So far, different approaches have been proposed to model and predict  the  stock price crash risk, which in most cases have been the main emphasis on the factors affecting it, and often traditional methods have been used for prediction. On the other hand, using  Meta Heuristic Alg...

A novel ZIF-8 assisted polyacrylamide functionalized silica polar stationary phase was prepared by a facile method of adding nanoparticles and into (PAM) aqueous solution, then stirring the mixture until solution evaporated absolutely with help mechanical agitator. Interestingly, (PAM-Sil@ZIF-8/PAM) showed favorable hydrophilicity, as demonstrated good separation performance strong retention ab...