Human cytomegalovirus (HCMV) infections of healthy individuals are mostly unnoticed and result in viral latency. However, HCMV can also cause devastating disease, e.g., upon reactivation in immunocompromised patients. Yet, little is known about human immune cell sensing of DNA-encoded HCMV. Recent studies indicated that during viral infection the cyclic GMP/AMP synthase (cGAS) senses cytosolic ...

Sting-ray injuries have recently had high profile media coverage following a rare fatality. However, minor injuries to the hands and feet are common. We present a case of a sting-ray injury to the hand. This was washed out under local anaesthetic at the local emergency department and was a delayed presentation to a specialist hand surgeon, 1 month post injury with severe pain. Ultrasound scan s...

In the early stages of human papillomavirus (HPV) infection, the viral proteins elicit specific immune responses that can participate to regression of ano-genital lesions. HPV E6 protein for instance can reduce type I interferon (IFN) including IFN-κ that is involved in immune evasion and HPV persistence. To evaluate the role of E2 protein in innate immunity in HPV16-associated cervical lesions...

on in France. The book represents a lay agitation for " twilight sleep," and describes the experiences of several women who have been delivered at Freiburg. From the obstetrical point of view, the principal interest lies in the three appendices where Kronig and Gauss give the details of the method and meet the various arguments which have been launched against " twilight sleep." The writers evi...

Using plugins as a mechanism for evolving applications is appealing, but current implementations are limited in scope. Plugins are optional components which can be used to enable the dynamic construction of flexible and complex systems, passing as much of the configuration management effort as possible to the system rather than the user, allowing graceful upgrading of systems over time without ...

very important point of view of the woman herself, and it consequently cannot be ignored. The book is a glorification of the Franen Klinik at Freiburgh run by Drs. Kronig and Gauss, and gives the detailed experiences of many women who have gone through the Klinik. It is written in a somewhat sensational style, but the fact remains that there exists in the United States a propaganda among women ...

UNLABELLED STING (stimulator of interferon [IFN] genes) initiates type I IFN responses in mammalian cells through the detection of microbial nucleic acids. The membrane-bound obligate intracellular bacterium Chlamydia trachomatis induces a STING-dependent type I IFN response in infected cells, yet the IFN-inducing ligand remains unknown. In this report, we provide evidence that Chlamydia synthe...

Various ocular and systemic reactions have been associated with insect sting. However, insect stings have been rarely reported to cause exotropia and diplopia. We encountered exotropia in a 6-year-old child with rhabdomyolysis of the left lower extremities caused by an insect sting. Exotropia and diplopia developed within 1 day after the sting and improved completely 1 week after the onset of s...

We report a case in which a 21-week pregnant woman was stung by a Euscorpius flavicaudis (De Geer, 1778) scorpion. Symptoms and signs experienced by the patient were the same as those documented in the literature and with no ill-effects for the pregnancy. Envenoming was local and of low degree of intensity. It is important to emphasize that the patient was stung in her home, which differs from ...