Chiral 3,3a,5,9b-tetrahydro-2H-furo[3,2-c][2]benzopyrans (TFBs) were synthesized and some of them were found to be herbicidally active against annual paddy weeds through intensive structure–activity relationship studies. These compounds were synthesized from D-glucose, which was used as a natural chiral source. This was the result of a series of studies based on the findings that certain benzyl...