Abstract Laboratory measurements of the interaction between high‐frequency (HF) wind‐waves and low frequency (LF) paddle waves are presented. The were made in a wind‐wave flume with wind propagating same direction. primary objective is to examine physical mechanisms proposed explain suppression due presence swell (here waves). For this purpose, precise time scale temporal transition from wind‐o...

β-Diguetoxin-Dc1a (Dc1a) is a toxin from the desert bush spider Diguetia canities that incapacitates insects at concentrations that are non-toxic to mammals. Dc1a promotes opening of German cockroach voltage-gated sodium (Nav) channels (BgNav1), whereas human Nav channels are insensitive. Here, by transplanting commonly targeted S3b-S4 paddle motifs within BgNav1 voltage sensors into Kv2.1, we ...

This case report presents salvage of a partially failing anterolateral thigh flap. A 37-year-old male, a victim of head and neck squamous cell carcinoma, received tumor ablation and a chimeric anterolateral thigh skin and vastus lateralis muscle flap reconstruction. Before ligation of pedicle, both skin and muscle portions had robust blood supply; however, only the vastus lateralis muscular com...

Peripheral nerve stimulation (PNS) has been used for the treatment of various neuropathic pain disorders, including occipital neuralgia, for the patients who failed less-invasive therapeutic approaches. Several different mechanisms of pain relief were proposed when PNS is used to treat occipital neuralgia and clinical studies using various types of electrical leads suggested largely positive cl...

The size of the movement and the molecular identity of the moving parts of the voltage sensor of a voltage-gated ion channel are debated. In the helical-screw model, the positively charged fourth transmembrane segment S4 slides and rotates along negative counter charges in S2 and S3, while in the paddle model, S4 carries the extracellular part of S3 (S3b) as a cargo. Here, we show that S4 slide...

This study describes various complications related to sample preparation (filtration) during development of a dissolution method intended to discriminate among different fenofibrate immediate-release formulations. Several dissolution apparatus and sample preparation techniques were tested. The flow-through cell apparatus (USP 4) was found unfit for dissolution testing of fenofibrate MeltDose fo...

The title coordination polymer, [Cu(C(6)H(3)BrNO(2))(2)](n), is composed of two structurally similar two-dimensional coordination polymers (twin layers). Both of them have the same chemical composition but they display different bond lengths and angles. In each layer, two N atoms and four carboxyl-ate O atoms from the bridging 5-bromo-nicotinate ligands and four carboxyl-ate O atoms from the te...

Carvedilol (BCS Class II drug) is a nonselective β-adrenergic blocking agent with α1-blocking activity and it is mainly used in the management of hypertension. Two commercial brands of carvedilol drug, of strength 12.5mg were used for the Invitro dissolution studies. In the present study four dissolution media [pH 1.2 (0.1 N Hcl), pH 4.5 Acetate buffer, pH 6.8 phosphate buffer, and Distilled wa...

The water wave generation by wave paddle and a freely falling rigid body are examined by using an Incompressible Smoothed Particle Hydrodynamics (ISPH). In the current ISPH method, the pressure was evaluated by solving pressure Poisson equation using a semi-implicit algorithm based on the projection scheme and the source term of pressure Poisson equation contains both of divergence free velocit...

The reconstruction of large scalp and dural defects is difficult. Anterolateral thigh (ALT) flap is now widely used because of its reliable blood supply to the skin paddle. Additionally, ALT can be harvested with a large skin paddle and large, well-vascularized fascia. We have successfully treated eight scalp and dural composite defect cases (five male and three female) using ALT with vasculari...