Cifuentes, M. Eugenia, Federico E. Rey, Oscar A. Carretero, and Patrick J. Pagano. Upregulation of p67 and gp91 in aortas from angiotensin II-infused mice. Am J Physiol Heart Circ Physiol 279: H2234–H2240, 2000.—Although NAD(P)H oxidase-derived superoxide (O2 ) is increased during the development of angiotensin II (ANG II)-dependent hypertension, vascular regulation at the protein level has not...

Khz is a compound derived from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia that inhibits the growth of cancer cells. The results of the present study show that Khz induced apoptosis preferentially in transformed cells and had only minimal effects on non-transformed cells. Furthermore, Khz induced apoptosis by increasing the intracellular Ca(2+) concentration ([Ca(2+)](i)) a...

The 67-kD cytosolic protein (p67-phox) is an essential component of the superoxide-generating system in phagocytes, and its defect is known to cause chronic granulomatous disease (CGD). We sequenced p67-phox cDNA from one of seven patients found in Japan and his parents. In the patient's cDNA, homozygous AG dinucleotide insertion at position 399 (or 401) was found together with three other homo...

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder due to a genetic defect in one of the components of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This complex is composed of membrane-bound gp91-phox and p22-phox subunits, and cytosolic subunits consisting of p47-phox, p67-phox, and p40-phox. A mutation in CYBB gene encoding gp91-phox locate...

Methods In this cross sectional study were included 115 asthmatic children and adolescents 9 to 19 years old and their mothers. For the children, asthma severity, PA level and exercise induced bronchospasm (EIB) were evaluated. The mothers were investigated on their beliefs about PA in non-asthmatic and asthmatic children, if they imposed restrictions to their children PA, perception of exercis...