CCG-2961 incorporated 3 new agents, idarubicin, fludarabine and interleukin-2, into a phase 3 AML trial using intensive-timing remission induction/consolidation and related donor marrow transplantation or high-dose cytarabine intensification. Among 901 patients under age 21 years, 5-year survival was 52%, and event-free survival was 42%. Survival improved from 44% between 1996 and 1998 to 58% b...

Abstract Aims We present short-term results from the personal series of laparoscopic TAPP inguinal hernia procedures performed during 1st year postgraduate in General Surgery. Material and Method Retrospective study where we analyzed our database patients diagnosed with undergoing surgical treatment using approach-TAPP. Results A total 77 underwent approach (men: 90%, age: 61(RIQ: 4 2.5–68 year...

A prominent feature of sickle cell anemia is the presence of dehydrated red blood cells (RBCs) in circulation. Loss of potassium (K(+)), chloride (Cl(-)), and water from RBCs is thought to contribute to the production of these dehydrated cells. One main route of K(+) loss in the RBC is the Gardos channel, a calcium (Ca(2+))-activated K(+) channel. Clotrimazole (CLT), an inhibitor of the Gardos ...

OBJECTIVE To compare nebulized racemic epinephrine delivered by 70% helium and 30% oxygen or 100% oxygen followed by helium-oxygen inhalation therapy via high-flow nasal cannula (HFNC) vs oxygen inhalation via HFNC in the treatment of bronchiolitis. DESIGN Prospective, randomized, controlled, single-blind trial. SETTING This study was conducted from October 1, 2004, through May 31, 2008, in...

CONTEXT Pancreatic cancer is an aggressive tumor associated with high mortality. Optimal pain control may improve quality of life (QOL) for these patients. OBJECTIVE To test the hypothesis that neurolytic celiac plexus block (NCPB) vs opioids alone improves pain relief, QOL, and survival in patients with unresectable pancreatic cancer. DESIGN, SETTING, AND PATIENTS Double-blind, randomized ...

OBJECTIVE This meta-analysis examined 53 controlled trials of cognitive-behavioral treatment (CBT) for adults diagnosed with alcohol- or illicit-drug-use disorders. The aims were to provide an overall picture of CBT treatment efficacy and to identify client or treatment factors predictive of CBT effect magnitude. METHOD The inverse variance weighted effect size (Hedges' g) was calculated for ...

BACKGROUND This study examines associations between perceptions of neighbourhood environment and physical activity and sports within Portuguese adolescents. METHODS The sample consisted of 4,877 individuals of both genders, with an average age of 14 years. The instrument used was the Health Behavior School-aged Children questionnaire. RESULTS Perceptions of the neighbourhood being unsafe fo...

OBJECTIVES To compare rapid sequence intubation (RSI) premedication with morphine for intubation of preterm infants. STUDY DESIGN Preterm infants needing semi-urgent intubation were enrolled to either RSI (glycopyrrolate, thiopental, suxamethonium, and remifentanil, n = 17) or atropine and morphine (n = 17) in a randomized trial. The main outcome was "good intubation conditions" (score ≤10 as...

Data were obtained from 1,908 pregnancies resulting from bovine embryo transfer procedures. Responses examined included sex ratio, fetal, neonatal and preweaning death losses, birth weight and calving assistance. The sex ratio for 1,751 embryo transfer calves examined was 51.11% males. Cows older than 10 yr that had become repeat breeders produced more (P less than .05) male calves than other d...

Six abomasally-cannulated wethers (average initial weight 18 kg) were used in a split 3 X 3 Latin square design experiment with a crossover to determine effects of glucose (G) administered orally (O) or infused (I) into the abomasum on nitrogen metabolism and forage fiber digestion. Basal diets were Coastal bermudagrass (CBG) or CBG treated with 1% formaldehyde (F-CBG). Individual treatments we...