DNA hypermethylation is common and plays a critical role in the regulation of gene expression. It is considered a major cause of carcinogenesis. High-throughput profiling method has been developed to analyze the methylation status of hundreds of pre-selected genes simultaneously. The aim of this study was to analyze promoter hypermethylation profiles of each subtype of ovarian epithelial cancer...

The primary olfactory nervous system is unique in that it continuously renews itself and regenerates after injury. These properties are attributed to the presence of olfactory glia, termed olfactory ensheathing cells (OECs). Evidence is now emerging that individual OEC populations exist with distinct anatomical localisations and physiological properties, but their differential roles have not be...

The water oxidation half-reaction is considered the bottleneck in development of technological advances to replace fossil fuels with sustainable and economically affordable energy sources. In natural photosynthesis, occurs oxygen evolving complex (OEC), a manganese-oxo cluster {Mn4CaO5} cubane-like topology that embedded within redox-active protein environment located photosystem II (PS II). Th...

This paper introduces a new graph problem to find an Optimal Euler Circuit (OEC) in an Euler graph. OEC is defined as the Euler circuit that maximizes the sum of contiguous costs along it, where the contiguous cost is assigned for each of the two contiguous edges incident to a vertex. We prove that the OEC problem is NP-complete. A polynomial time algorithm will be presented for the case of a g...

The elderly population has experienced increased life expectancy as well as the increased incidence of gastric ulcers. The peels of fruits from Citrus aurantium L., popularly known in Brazil as orange bitter, are commonly used asatea form for the treatment of gastrointestinal tract disorders, such as ulcer and gastritis. We evaluated the healing effects of essential oil from the peels of Citrus...

Amines inhibit photosynthetic oxygen evolution by binding to manganese in the oxygen evolving complex. This inhibition is more effective if chloride is absent. Steady-state kinetic analyses show that ammonia and chloride compete for the same site in the oxygen evolving complex; inhibition of oxygen evolution by either chloride depletion or by ammonia addition induces Signal IIr, which saturates...

Oxygen, that supports all aerobic life, is abundant in the atmosphere because of its constant regeneration by photosynthetic water oxidation, which is catalyzed by a Mn₄CaO₅ cluster in photosystem II (PS II), a multi subunit membrane protein complex. X-ray and other spectroscopy studies of the electronic and geometric structure of the Mn₄CaO₅ cluster as it advances through the intermediate stat...