The oxygen limitation hypothesis states that hepatocyte hypoxia is the mechanism determining metabolic restriction in the cirrhotic liver. Therefore we studied markers of hepatocyte energy state and cellular hypoxia in livers of normal and cirrhotic rats before and after oxygen supplementation. Rats with carbon tetrachloride-induced cirrhosis and procedural control rats were exposed to either r...

The cardiovascular and acid-base changes following equivalent i.v. bolus doses of sodium nitroprusside (SNP) and potassium cyanide (KCN) have been studied in two groups of anaesthetized dogs. In a third group, the metabolic changes produced by i.v. infusion of SNP 1.5 mg kg-1 at a constant rate over 1 h have been studied. In contrast to a decrease in arterial pressure following SNP, hypertensio...

Friedreich ataxia is due to insufficient levels of frataxin, a mitochondrial iron chaperone that shields this metal from reactive oxygen species (ROS) and renders it bioavailable as Fe II. Frataxin participates in the synthesis of iron-sulfur clusters (ISCs), cofactors of several enzymes, including mitochondrial and cytosolic aconitase, complexes I, II and III of the respiratory chain, and ferr...

In this research work, environmental monitoring processes and assessments are carried out by the modeling analysis of water quality Chambal River in state Rajasthan. Various samples were collected from different locations along course river flow. This is used for kinds human, animal, agriculture corp. activities. Comparative analyses conducted on parameters, viz. biochemical oxygen demand, chem...

Many evidences strongly suggest that a mitochondrial deficit is implicated in major depression. A mitochondrial deficit leads to mitochondrial stress responses, including the mitochondrial unfolded protein response (UPRmt), which is associated with certain brain disorders such as spastic paraplegia and Parkinson's disease. However, there is no evidence regarding the relationship between depress...

The main finding of this study was that for heat acclimatised athletes, there was no significant difference (p=0.58) in anaerobic capacity for temperate (21.8 ± 0.5 °C; 52 ± 5 % relative humidity) compared with warm conditions (29.6 ± 0.5 °C; 51 ± 9 % relative humidity). Anaerobic capacity was estimated using the maximal accumulated oxygen deficit (MAOD) during constant intensity cycling at 120...

Arterialized venous blood was used to investigate maternal acid-base state during the first and second stages of normal labour. During labour the range of values obtained for acid-base variables is wide but patterns are discernible. At the beginning of labour Pco, was lower than it is in non-pregnant subjects, and the pH was higher despite a substantial base deficit. At the end of the first sta...

We examined the hypothesis that O2 uptake (VO2) would change more rapidly at the onset of step work rate transitions in exercise with hyperoxic gas breathing and after prior high-intensity exercise. The kinetics of VO2 were determined from the mean response time (MRT; time to 63% of total change in VO2) and calculations of O2 deficit and slow component during normoxic and hyperoxic gas breathin...

Sir, I am grateful to Karnath and his colleague (Karnath and Smith, 2014) for a sophisticated commentary on our recent study (Mah et al., 2014); nonetheless, four aspects of their analysis may cause some readers to misapprehend our conclusions in a way that will tend to perpetuate the errors it was our original aim to correct. First, the principal reason for changing to multivariate inference i...

PURPOSE Cross-country-ski races place complex demands on athletes, with events lasting between approximately 3 min and 2 h. The aim of the current study was to compare the aerobic and anaerobic measures derived from a short time trial (TT) between male and female skiers using diagonal cross-country skiing. METHODS Twenty-four highly trained cross-country skiers (12 male and 12 female, age 17....