Background Opioids are an effective treatment for moderate-to-severe pain. However, they are associated with a number of gastrointestinal side effects, most commonly constipation. Laxatives do not target the underlying mechanism of opioid-induced constipation (OIC), so many patients do not have their symptoms resolved. Fixed-dose prolonged-release (PR) oxycodone/naloxone (OXN) tablets contain t...

PURPOSE To evaluate the repair process in rats with experimentally induced arterial hypertension. This study aimed to evaluate lesions in the ventricular myocardium and the repair process during experimental hypertension induced by systemic blockage of nitric oxide using N-omega-nitro-L-arginine methyl ester hydrochloride (L-NAME). Nitric oxide is an endothelial vasorelaxing factor and is neces...

7 ABSTRACT: The biomimetic oxomanganese complex [Mn2(μ8 O)2(terpy)2(OH2)2](NO3)3 (1; terpy = 2,2′:6′,2′′-terpyridine) catalyzes O2 9 evolution from water when activated by oxidants, such as oxone (2KHSO5· 10 KHSO4·K2SO4). The mechanism of this reaction has never been characterized, 11 due to the fleeting nature of the intermediates. In the present study, we 12 elucidate the underlying reaction ...

Capillary electrophoresis (CE) and electrospray ionisation (ESI) mass spectra of aqueous solutions of manganese(II) complexes of the monoanions of the pentadentate ligands N-methyl-N'-carboxymethyl-N,N'-bis(2-pyridylmethyl)ethane-1,2-diamine (mcbpen(-)) and N-benzyl-N'-carboxymethyl-N,N'-bis(2-pyridylmethyl)ethane-1,2-diamine (bcbpen(-)), show the presence of a mixture of closely related Mn(II)...